Biological Biomarker
Mostrando 1-12 de 49 artigos, teses e dissertações.
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1. BIOMARCADORES MOLECULARES DE DOENÇAS HUMANAS: CONCEITOS FUNDAMENTAIS, MODELOS DE ESTUDO E APLICAÇÕES CLÍNICAS
Molecular biomarkers correspond to all endogenous or exogenous biomolecules, whose presence or alteration in metabolic pathways indicate the response of a biological system to a disturbance caused by internal or external factors. The search for biomarkers has allowed deepening the knowledge of complex pathophysiological mechanisms of diseases, interactions w
Química Nova. Publicado em: 2022
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2. PADRONIZAÇÃO DA QUANTIFICAÇÃO DE GLUTATIONA REDUTASE EM Aegla singularis (ANOMURA, CRUSTACEA) UTILIZANDO PLANEJAMENTO EXPERIMENTAL DCCR
Glutathione Reductase (GR) plays a key role in the maintenance of GSH homeostasis, variations in its activity may indicate damage from environmental contaminants. Experimental planning is a strategy to reduces time and cost in enzymatic assays. In this work, DCCR experimental planning was used to standardize and to validate the measure of GR in Aegla singula
Quím. Nova. Publicado em: 2020-05
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3. Mechanisms and biomarker candidates in pterygium development
RESUMO A patogênese do pterígio tem sido relacionada, prin cipalmente, à exposição à luz ultravioleta, mas esta asso ciação permanece bastante controversa. O mecanismo completo do pte rígio também permanece por esclarecer. Fatores como inflamação, infecção viral, estresse oxidativo, metilação do DNA, mediadores inflamatórios, moduladores de
Arq. Bras. Oftalmol.. Publicado em: 30/09/2019
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4. Schizophrenia TreAtment with electRic Transcranial Stimulation (STARTS): design, rationale and objectives of a randomized, double-blinded, sham-controlled trial
Resumo Introdução A esquizofrenia é um transtorno mental grave. Embora alguns medicamentos antipsicóticos tenham demonstrado eficácia no tratamento de sintomas positivos, não há tratamento amplamente reconhecido para sintomas negativos, o que pode causar sofrimento e prejuízo significativos para pacientes com esquizofrenia. Aqui descrevemos a funda
Trends Psychiatry Psychother.. Publicado em: 19/06/2019
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5. BjussuLAAO-II induces cytotoxicity and alters DNA methylation of cell-cycle genes in monocultured/co-cultured HepG2 cells
Abstract Background: The use of animal venoms and their toxins as material sources for biotechnological applications has received much attention from the pharmaceutical industry. L-amino acid oxidases from snake venoms (SV-LAAOs) have demonstrated innumerous biological effects and pharmacological potential against different cancer types. Hepatocellular carc
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 11/03/2019
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6. Interleukin-12 as a biomarker of the beneficial effects of food restriction in mice receiving high fat diet or high carbohydrate diet
The impact of food restriction (FR) during 56 days on serum levels of cytokines in mice fed a high-fat diet (HFD) or high-carbohydrate diet (HCD) were evaluated. The amount of food was reduced 50% for HFD-FR and HCD-FR groups compared to mice receiving free access to HFD (HFD group) or HCD (HCD group). We quantified the serum levels of basic fibroblast growt
Braz J Med Biol Res. Publicado em: 14/11/2018
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7. Exosomes as Biomarker of Cancer
ABSTRACT Rapid advances in medicine and biotechnology resulted in the development of non-invasive diagnostic and prognostic biomarkers enabling convenient and accurate detection. Exosomes has recently emerged as non-invasive biomarker for a number of diseases including cancer. Exosomes are the small endosome originated membranous vesicles secreted in a numbe
Braz. arch. biol. technol.. Publicado em: 08/10/2018
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8. Metabolomics as a promising tool for early osteoarthritis diagnosis
Osteoarthritis (OA) is the main cause of disability worldwide, due to progressive articular cartilage loss and degeneration. According to recent research, OA is more than just a degenerative disease due to some metabolic components associated to its pathogenesis. However, no biomarker has been identified to detect this disease at early stages or to track its
Braz J Med Biol Res. Publicado em: 21/09/2017
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9. Biological significance of miR-126 expression in atrial fibrillation and heart failure
We investigated the biological significance of microRNA-126 (miR-126) expression in patients with atrial fibrillation (AF) and/or heart failure (HF) to examine the possible mechanism of miR-126-dependent AF and development of HF. A total of 103 patients were divided into three groups: AF group (18 men and 17 women, mean age: 65.62±12.72 years), HF group (17
Braz J Med Biol Res. Publicado em: 25/08/2015
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10. Biomarkers in mood disorders research: developing new and improved therapeutics
Background Recently, surrogate neurobiological biomarkers that correlate with target engagement and therapeutic response have been developed and tested in early phase studies of mood disorders. Objective The identification of biomarkers could help develop personalized psychiatric treatments that may impact public health. Methods These biomarkers, which are
Arch. Clin. Psychiatry (São Paulo). Publicado em: 2014
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11. cagE as a biomarker of the pathogenicity of Helicobacter pylori
IntroductionHelicobacter pylori infection is associated with gastro-duodenal diseases. Genes related to pathogenicity have been described for H. pylori and some of them appear to be associated with more severe clinical outcomes of the infection. The present study investigates the role of cagE as a pathogenicity biomarker of H. pylori compare it to cagA, vacA
Rev. Soc. Bras. Med. Trop.. Publicado em: 2013-04
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12. Identificação de alvos protéicos com potencial diagnóstico e prognóstico em doença arterial coronária / Identification of protein targets with potential diagnostic and prognostic in coronary artery disease
Worldwide, millions of patients are treated in emergencies because they had acute-onset chest pain, but only a portion is due to coronary syndrome. In situations like this is extremely important to distinguish when the chest pain is due to myocardial ischemia, as this is high risk and initiation of treatment should be immediate. New biomarkers are needed to
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/06/2012