cagE as a biomarker of the pathogenicity of Helicobacter pylori
AUTOR(ES)
Ramis, Ivy Bastos, Vianna, Júlia Silveira, Silva Junior, Lande Vieira da, Von Groll, Andrea, Silva, Pedro Eduardo Almeida da
FONTE
Rev. Soc. Bras. Med. Trop.
DATA DE PUBLICAÇÃO
2013-04
RESUMO
IntroductionHelicobacter pylori infection is associated with gastro-duodenal diseases. Genes related to pathogenicity have been described for H. pylori and some of them appear to be associated with more severe clinical outcomes of the infection. The present study investigates the role of cagE as a pathogenicity biomarker of H. pylori compare it to cagA, vacA, iceA and babA2 genes and correlate with endoscopic diagnoses.MethodsWere collected biopsy samples of 144 dyspeptic patients at the Hospital of the Federal University of Rio Grande, Rio Grande do Sul, Brazil. After collection, the samples were sent for histological examination, DNA extraction and detection of all putative pathogenicity genes by PCR.ResultsOf the 144 patients undergoing endoscopy, 57 (39.6%) presented H. pylori by histological examination and PCR by detection of the ureA gene. Based on the endoscopic diagnoses, 45.6% (26/57) of the patients had erosive gastritis, while 54.4% (31/57) had enanthematous gastritis. The genes cagA, cagE, vacAs1/m1, vacAs1/m2 and iceA1 were related to erosive gastritis, while the genes vacAs2/m2, iceA2 and babA2 were associated to enanthematous gastritis. We found a statistically significant association between the presence of cagE and the endoscopic diagnosis. However, we detect no statistically significant association between the endoscopic diagnosis and the presence of cagA, vacA, iceA and babA2, although a biological association has been suggested.ConclusionsThus, cagE could be a risk biomarker for gastric lesions and may contribute to a better evaluation of the H. pylori pathogenic potential and to the prognosis of infection evolution in the gastric mucosa.
Documentos Relacionados
- Authors reply: cagE as a biomarker of the pathogenicity of Helicobacter pylori
- Helicobacter pylori cagE is not associated with clinical outcomes in the Kurdistan region of Iraq
- Characterization and Immunogenicity of the CagF Protein of the cag Pathogenicity Island of Helicobacter pylori
- Sequence anomalies in the Cag7 gene of the Helicobacter pylori pathogenicity island
- Distinct Diversity of the cag Pathogenicity Island among Helicobacter pylori Strains in Japan