Attenuated Vaccines
Mostrando 1-12 de 346 artigos, teses e dissertações.
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1. The mc2-CMX vaccine induces an enhanced immune response against Mycobacterium tuberculosis compared to Bacillus Calmette-Guérin but with similar lung inflammatory effects
Although the attenuated Mycobacterium bovis Bacillus Calmette-Guérin (BCG) vaccine has been used since 1921, tuberculosis (TB) control still proceeds at a slow pace. The main reason is the variable efficacy of BCG protection against TB among adults, which ranges from 0-80%. Subsequently, the mc2-CMX vaccine was developed with promising results. Nonetheless,
Mem. Inst. Oswaldo Cruz. Publicado em: 2016-04
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2. Full-length infectious clone of a low passage dengue virus serotype 2 from Brazil
Full-length dengue virus (DENV) cDNA clones are an invaluable tool for many studies, including those on the development of attenuated or chimeric vaccines and on host-virus interactions. Furthermore, the importance of low passage DENV infectious clones should be highlighted, as these may harbour critical and unique strain-specific viral components from field
Mem. Inst. Oswaldo Cruz. Publicado em: 17/07/2015
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3. Live bacterial vaccine vectors: An overview
Genetically attenuated microorganisms, pathogens, and some commensal bacteria can be engineered to deliver recombinant heterologous antigens to stimulate the host immune system, while still offering good levels of safety. A key feature of these live vectors is their capacity to stimulate mucosal as well as humoral and/or cellular systemic immunity. This enab
Braz. J. Microbiol.. Publicado em: 2014-12
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4. Vaccines for preventing herpes zoster in older adults
BACKGROUND:Herpes zoster or, as it is commonly called, 'shingles' is a neurocutaneous disease characterised by the reactivation of varicella zoster virus (VZV), the virus that causes chickenpox, which is latent in the dorsal spinal ganglia when immunity to VZV declines. It is an extremely painful condition which can often last for many weeks or months, impai
Sao Paulo Med. J.. Publicado em: 2014
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5. Inhibition of rotavirus ECwt infection in ICR suckling mice by N-acetylcysteine, peroxisome proliferator-activated receptor gamma agonists and cyclooxygenase-2 inhibitors
Live attenuated vaccines have recently been introduced for preventing rotavirus disease in children. However, alternative strategies for prevention and treatment of rotavirus infection are needed mainly in developing countries where low vaccine coverage occurs. In the present work, N-acetylcysteine (NAC), ascorbic acid (AA), some nonsteroidal anti-inflammato
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-09
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6. Construção de linhagens atenuadas de Salmonella enterica Enteritidis : avaliação do potencial imunogênico e protetor / Cosntruction of attenuated Salmonella enterica Enteritidis strains : evaluation of its immunogenic and protective potential
Salmonella enterica é uma bactéria Gram-negativa classificada em diferentes sorovariedades que podem causar desde gastroenterites a infecções sistêmicas. A sorovariedade Enteritidis é predominante nos casos de salmonelose em humanos, tendo produtos derivados do frango como principal fonte de infecção. Uma forma de se controlar infecções por Enterit
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 04/06/2012
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7. Construção de linhagens atenuadas de S. enterica Typhimurium produtoras de antígeno de Plasmodium / Construction of attenuated strains of S. enterica Typhimurium producing antigen of Plasmodium
A Salmonelose e a malária são duas doenças infecciosas negligenciadas de grande prevalência no mundo, mas acometendo particularmente populações humanas que vivem em regiões e países subdesenvolvidos ou em desenvolvimento. Apesar dos esforços ainda não existem formulações vacinais totalmente efetivas no controle destas enfermidades. Desta forma, n
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/02/2012
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8. Vaccines for post-exposure prophylaxis against varicella (chickenpox) in children and adults
BACKGROUND: Live attenuated varicella vaccines for the prevention of varicella (chickenpox) has been demonstrated both in randomised controlled trials (RCTs) and in population-based immunisation programmes in countries such as the United States. However, many countries do not routinely immunise children against varicella, and exposures continue to occur. Alt
Sao Paulo Medical Journal. Publicado em: 2012
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9. A bovine herpesvirus 5 recombinant defective in the thymidine kinase (TK) gene and a double mutant lacking TK and the glycoprotein E gene are fully attenuated for rabbits
Bovine herpesvirus 5 (BoHV-5), the agent of herpetic meningoencephalitis in cattle, is an important pathogen of cattle in South America and several efforts have been made to produce safer and more effective vaccines. In the present study, we investigated in rabbits the virulence of three recombinant viruses constructed from a neurovirulent Brazilian BoHV-5 s
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-02
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10. CARACTERIZAÇÃO DE GENES DO VÍRUS DO ECTIMA CONTAGIOSO ENVOLVIDOS NA REGULAÇÃO DA VIA DE SINALIZAÇÃO DO NF-κB / CHARACTERIZATION OF ORF VIRUS-ENCODED GENES INVOLVED IN THE REGULATION OF THE NF-κB SIGNALING PATHWAY
Orf virus (ORFV), the type member of the genus Parapoxvirus of the family Poxviridae, is the etiologic agent of orf or contagious ecthyma, a contagious and ubiquitous disease of sheep and goats. ORFV genome consists of a double stranded DNA molecule with approximately 138 Kb, and contains 131 putative genes. Among those, 15 are novel genes, unique to parapox
Publicado em: 2010
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11. Is an HIV vaccine possible?
The road to the discovery of a vaccine for HIV has been arduous and will continue to be difficult over the ensuing twenty years. Most vaccines are developed by inducing neutralizing antibodies against the target pathogen or by using attenuated strains of the particular pathogen to engender a variety of protective immune responses. Unfortunately, simple metho
Brazilian Journal of Infectious Diseases. Publicado em: 2009-08
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12. Occurrence of chicken anemia virus in backyard chickens of the metropolitan region of Belo Horizonte, Minas Gerais
The occurrence of CAV in backyard chickens in the metropolitan area of Belo Horizonte, Brazil, was evaluated. The spleen and thymus of chickens from different origins were collected for DNA extraction and nested-PCR. CAV genome was detected in 30% of the flocks (n=20) examined. CAV origin for backyard chickens is speculated, taking into consideration its wid
Revista Brasileira de Ciência Avícola. Publicado em: 2009-06