Vitamin E: characterization of the biological activity and relation with the nuclear receptor PPARy. / Vitamina E: caracterização da atividade biológica na resposta inflamatória induzida pelo LPS e sua relação com o receptor nuclear PPARy.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

Vitamin E, a generic term to describe a group of structurally lipophilic molecules (tocopherols and tocotrienols), is one of the most known antioxidants and it has been studied also because its non-antioxidant roles. By the way, depending on the administered dose, -tocopherol can exert antagonic effects in vitro. Its known that PPAR, a nuclear receptor involved in transcription of inflammatory genes, can be related to -tocopherol effects. Considering this, our group decided to characterize the -tocopherol activity in an mice peritoneal LPS-induced inflammation model and its possible relationship with PPAR receptor. In this work, we show for the first time that -tocopherol can exert antagonic effects in an IN VIVO inflammatory model and that anti-inflammatory activity involves KC secretion inhibition. In parallel, PPAR activation enhances the response in the same model, showing that this receptor exerts proinflammatory role in LPS-induced response IN VIVO. In addition, rosiglitazone, a PPAR agonist, upregulates KC secretion in vitro, but its activity is inhibit by -tocopherol treatment. Transfection assays also show that -tocopherol can act through PPAR signaling pathway. In conclusion, -Tocopherol is an important antiinflammatory agent in LPS-induced response and its action involves down regulate of KC secretion by PPAR activity inhibition.

ASSUNTO(S)

ppar gamma ppar gama tocopherols tocoferóis lipopolysaccharides farmacologia bioquimica e molecular vitamina e lipopolissacarídeos vitamin e

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