Visual arrestins in olfactory pathways of Drosophila and the malaria vector mosquito Anopheles gambiae
AUTOR(ES)
Merrill, C. E.
FONTE
The National Academy of Sciences
RESUMO
Arrestins are important components for desensitization of G protein-coupled receptor cascades that mediate neurotransmission as well as olfactory and visual sensory reception. We have isolated AgArr1, an arrestin-encoding cDNA from the malaria vector mosquito, Anopheles gambiae, where olfaction is critical for vectorial capacity. Analysis of AgArr1 expression revealed an overlap between chemosensory and photoreceptor neurons. Furthermore, an examination of previously identified arrestins from Drosophila melanogaster exposed similar bimodal expression, and Drosophila arrestin mutants demonstrate impaired electrophysiological responses to olfactory stimuli. Thus, we show that arrestins in Drosophila are required for normal olfactory physiology in addition to their previously described role in visual signaling. These findings suggest that individual arrestins function in both olfactory and visual pathways in Dipteran insects; these genes may prove useful in the design of control strategies that target olfactory-dependent behaviors of insect disease vectors.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=122242Documentos Relacionados
- An Integrated Genetic Map of the African Human Malaria Vector Mosquito, Anopheles Gambiae
- Immune signaling pathways regulating bacterial and malaria parasite infection of the mosquito Anopheles gambiae
- Physical Map of the Malaria Vector Anopheles Gambiae
- A highly conserved candidate chemoreceptor expressed in both olfactory and gustatory tissues in the malaria vector Anopheles gambiae
- Low-resolution genome map of the malaria mosquito Anopheles gambiae.