Immune signaling pathways regulating bacterial and malaria parasite infection of the mosquito Anopheles gambiae
AUTOR(ES)
Meister, Stephan
FONTE
National Academy of Sciences
RESUMO
We show that, in the malaria vector Anopheles gambiae, expression of Cecropin 1 is regulated by REL2, an NF-κB-like transcription factor orthologous to Drosophila Relish. Through alternative splicing, REL2 produces a full-length (REL2-F) and a shorter (REL2-S) protein isoform lacking the inhibitory ankyrin repeats and death domain. RNA interference experiments show that, in contrast to Drosophila Relish, which responds solely to Gram-negative bacteria, the Anopheles REL2-F and REL2-S isoforms are involved in defense against the Gram-positive Staphylococcus aureus and the Gram-negative Escherichia coli bacteria, respectively. REL2-F also regulates the intensity of mosquito infection with the malaria parasite, Plasmodium berghei. The adaptor IMD shares the same activities as REL2-F. Microarray analysis identified 10 additional genes regulated by REL2, including CEC3, GAM1, and LRIM1.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1183586Documentos Relacionados
- Molecular immune responses of the mosquito Anopheles gambiae to bacteria and malaria parasites
- Visual arrestins in olfactory pathways of Drosophila and the malaria vector mosquito Anopheles gambiae
- Low-resolution genome map of the malaria mosquito Anopheles gambiae.
- Immune response of Anopheles gambiae to the early sporogonic stages of the human malaria parasite Plasmodium falciparum
- Genome expression analysis of Anopheles gambiae: Responses to injury, bacterial challenge, and malaria infection