Tratamento com topiramato melhora a sensibilidade hipotalâmica à insulina em camundongos obesos / Topiramate improves insulin sigmalling the hypothalamus of mice on high-fat diet
AUTOR(ES)
Érica Penteado
FONTE
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia
DATA DE PUBLICAÇÃO
18/11/2011
RESUMO
Topiramate (TPM) is an anticonvulsant drug used for the treatment of epilepsy and prophylaxis of migraine. Weight loss is a frequently side effect reported in patients and animal models treated with TPM. In animal models topiramate may increase levels of hypothalamic corticotropic-releasing hormone (CRH), which is an anorexigenic neuropeptide and may decrease food intake. Some studies showed that topiramate may decrease energy storage, and thus increase energy expenditure and thermogenesis. However, the mechanisms by which TPM reduces body weight are not completely known so far. The hypothalamus is acknowledged as an important regulator of whole-body energy homeostasis by integrating nutrient and hormones signals from central and peripheral inputs. Anorexigenic hormones such as insulin and leptin regulate the activity of distinct neuron populations that control energy balance via IR/PI3K/Akt/Foxo1 pathway or OBR/JAK2/STAT3 pathway respectively. However, if topiramate alters hypothalamic insulin or leptin sensitivity is not known. Thus, in the present study, we asked whether topiramate treatment alters energy balance by altering insulin and leptin action/signaling in the hypothalamus from control and diet-induced obesity (DIO) mice. Our data provide evidence that short treatment with topiramate improves hypothalamic insulin and leptin signaling and action in obese mice. The improvement of hypothalamic insulin and leptin may reduce food ingestion and increase energy expenditure by increases in CRH and TRH mRNA expression. The lower food intake and higher energy expenditure induced by topiramate treatment may reduce obesity in mice on high fat feeding and may be an alternative therapy for obese treatment.
ASSUNTO(S)
insulina hipotálamo metabolismo energético ingestão de alimentos obesidade insulin hypothalamus energy metabolism eating obesity
ACESSO AO ARTIGO
http://libdigi.unicamp.br/document/?code=000843944Documentos Relacionados
- Dieta hiperlipídica e envelhecimento modificam a sensibilidade à insulina e a expressão das proteinas relacionadas à via intracelular da insulina em hipotálamo de camundongos fêmeas.
- Caracterização da disfunção erétil em camundongos obesos tratados com dieta hiperlipídica
- EGFR Tyrosine Kinase Inhibitor (PD153035) Improves Glucose Tolerance and Insulin Action in High-Fat Diet–Fed Mice
- Investigation of the antioxidant activity of chitooligosaccharides on mice with high-fat diet
- α-Linolenic acid prevents hepatic steatosis and improves glucose tolerance in mice fed a high-fat diet