Thiazolidin-4-ones from 3-(Aminomethyl)pyridine, Arenealdehydes and Mercaptoacetic Acid: Synthesis and Radical Scavenger Activity

AUTOR(ES)

Neves, Adriana M., Duval, Auri R., Berwaldt, Gabriele A., Gouvêa, Daniela P., Flores, Natália P., Silva, Pâmela G. da, Stefanello, Francieli M., Cunico, Wilson

FONTE

J. Braz. Chem. Soc.

DATA DE PUBLICAÇÃO

2015-02

RESUMO

The efficient synthesis of fifteen novel thiazolidin-4-ones from reaction of 3-(aminomethyl) pyridine (3-picolylamine), arenealdenhydes and mercaptoacetic acid was described. The desired compounds were obtained in moderated to good yields by two methodologies: conventional heating and ultrasound irradiation. The thiazolidin-4-ones were fully identified and characterized by nuclear magnetic resonance (NMR), gas chromatography coupled to mass spectrometry (GC‑MS) and high resolution mass spectrometry (HRMS) techniques. Four compounds showed radical scavenger activity in the 2,2’-azinobis-3-ethyl-benzothiazoline-6-sulfonic acid (ABTS) assay.

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