The LINE-1 DNA sequences in four mammalian orders predict proteins that conserve homologies to retrovirus proteins.
AUTOR(ES)
Fanning, T
RESUMO
Recent work suggests that one or more members of the highly repeated LINE-1 (L1) DNA family found in all mammals may encode one or more proteins. Here we report the sequence of a portion of an L1 cloned from the domestic cat (Felis catus). These data permit comparison of the L1 sequences in four mammalian orders (Carnivore, Lagomorph, Rodent and Primate) and the comparison supports the suggested coding potential. In two separate, noncontiguous regions in the carboxy terminal half of the proteins predicted from the DNA sequences, there are several strongly conserved segments. In one region, these share homology with known or suspected reverse transcriptases, as described by others in rodents and primates. In the second region, closer to the carboxy terminus, the strongly conserved segments are over 90% homologous among the four orders. One of the latter segments is cysteine rich and resembles the putative metal binding domains of nucleic acid binding proteins, including those of TFIIIA and retroviruses.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=340631Documentos Relacionados
- Mus Spretus Line-1 Sequences Detected in the Mus Musculus Inbred Strain C57bl/6j Using Line-1 DNA Probes
- Analysis of LINE-1 family sequences on a single monkey chromosome.
- Translation of LINE-1 DNA elements in vitro and in human cells.
- Frequent Human Genomic DNA Transduction Driven by LINE-1 Retrotransposition
- Preferred sequences for DNA recognition by the TAL1 helix-loop-helix proteins.
