RESGATE DA REAÇÃO DE DEBUS-RADZISZEWSKI: ENSINO PRÁTICO DE REAÇÕES MULTICOMPONENTES NA SÍNTESE DA LOFINA
AUTOR(ES)
Santos, Victória Laysna dos Anjos; Gonsalves, Arlan de Assis; Araújo, Cleônia Roberta Melo
FONTE
Quím. Nova
DATA DE PUBLICAÇÃO
2020-09
RESUMO
Multicomponent reactions are attractive for the development of bioactive substances, being a one-pot synthesis allows a quick and efficient synthesis, and allows the construction of a diversity of privileged structures. The Debus-Radziszewski reaction, a classic example of a multicomponent reaction for obtaining 2,4,5-tri-substituted imidazole, was used to compose a didactic sequence to be applied in undergraduate courses in the following disciplines: Organic Chemistry, Experimental Chemistry, Pharmaceutical Chemistry and Medicinal Chemistry. Thus, the classes were planned and applied, one theoretical and two experimental, the synthesis of lofin (2,4,5-triphenyl-1H-imidazole) and the characterization of the product. The Debus-Radziszewski reaction for the preparation the lofin, proved to be suitable for practical class of multicomponent reactions, as it uses accessible reagents and equipment, it is easy to do and the students can follow the progress of the reaction visually. In addition, the didactic sequence inserts students in a contextualized and interdisciplinary way in the practical chemistry procedures, employing a classic reaction, but with current perspectives of Organic and Medicinal Chemistry, such as the synthesis of the privileged fragments of bioactive compounds.
Documentos Relacionados
- Reações multicomponentes na preparação de compostos nitrogenados polifuncionalizados
- Metátese de fechamento de anel: espiro-anelação estereosseletiva
- "Aplicação da reação de heck na sintese de compostos heterociclicos"
- Reações multicomponentes de Biginelli e de Mannich nas aulas de química orgânica experimental: uma abordagem didática de conceitos da química verde
- A INFLUÊNCIA DA LIGAÇÃO DE HIDROGÊNIO EM REAÇÕES QUÍMICAS: REAÇÃO DE PRILESCHAJEW