RESGATE DA REAÇÃO DE DEBUS-RADZISZEWSKI: ENSINO PRÁTICO DE REAÇÕES MULTICOMPONENTES NA SÍNTESE DA LOFINA

Multicomponent reactions are attractive for the development of bioactive substances, being a one-pot synthesis allows a quick and efficient synthesis, and allows the construction of a diversity of privileged structures. The Debus-Radziszewski reaction, a classic example of a multicomponent reaction for obtaining 2,4,5-tri-substituted imidazole, was used to compose a didactic sequence to be applied in undergraduate courses in the following disciplines: Organic Chemistry, Experimental Chemistry, Pharmaceutical Chemistry and Medicinal Chemistry. Thus, the classes were planned and applied, one the...