RepercussÃo da desnutriÃÃo e do treinamento aerÃbio moderado sobre a estrutura da parede arterial de ratos em processo de envelhecimento

AUTOR(ES)

Vitor Caiaffo Brito

DATA DE PUBLICAÇÃO

2009

RESUMO

We evaluated the late effects of multideficient diet in early period of lactation and the possible effects and/or some alterations due to aging and moderate aerobic training (MAT) in luminal diameter and intima-media area of left common carotid arteries, horizontal aorta and thoracic horizontal aorta walls. Twenty-four male rats, Wistar, were separated according to diet and aerobic trainnig in: SNG â Sedentary nourished, TNG - Trained nourished; SMG - Sedentary malnourished and TMG - Trained malnourished. At 10 months of life, TNG and TMG were submitted to AT in aquatic device for 8 weeks. Then the rats were anesthetized, sacrificed, and later, arterial fragments were collected for histological processing. The intima-media area of blood vessels were measured by the difference between external and internal areas of the arterial wall; and luminal diameter was measured from the average of 2 diameters measured starting at 4 points marked on the inner layer of the vessel. It was observed a decrease in the intima-media area of horizontal aorta when we compared the groups SNG (335566.83 Â 58149.13) x SMG (259487.72 Â 51742.44), [p = 0.015] and an increase in left common carotid artery between the groups TNG (36531.42 Â 4164.45) and SNG (23663.72 Â 3036.43) [p = <0.001]. It was observed an increase in the thoracic aorta luminal diameter when we compared the SMG (798.98 Â 69.83) with TMG (980.35 Â 154.62) [p = 0.041]. Multicarencial diet induced, partially, changes in horizontal aortic wall; and the exercise, also partially, promoted changes in the intima-media area of the left common carotid artery and thoracic aorta luminal diameter

ASSUNTO(S)

remodelamento arterial multideficient diet arterial remodeling desnutriÃÃo multicarencial aging envelhecimento. treinamento aerÃbio anatomia patologica e patologia clinica aerobic exercise

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