Pyrimidine alkaloids from Eudistoma vannamei

AUTOR(ES)

Takeara, Renata, Basso, Thiago Olitta, Jimenez, Paula Christine, Costa-Lotufo, Letícia Veras, Lopes, Norberto Peporine, Lopes, João Luis Callegari

FONTE

Rev. bras. farmacogn.

DATA DE PUBLICAÇÃO

2015-12

RESUMO

Abstract Methanolic extracts of the Brazilian endemic ascidian Eudistoma vannamei have been extensively studied for their cytotoxic activity against several human cancer cell lines. Previous work reported the occurrence of purine derivatives and staurosporine alkaloids as the major nitrogen-containing compounds. In this study, we report the occurrence of three pyrimidine alkaloids in addition to cholesterol, sitosterol and stigmasterol.

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