PrevalÃncia dos subtipos do vÃrus da imunodeficiÃncia humana do tipo 1 (HIV-1) no estado do Piauà - Brasil e o perfil de resistÃncia das cepas identificadas. / Subtipes prevalence of human imunodeficient virus type 1 (HIV-1) in Piauà state/Brazil and the resistance profile of the studies virus.

AUTOR(ES)

Symonara Karina Medeiros Faustino

FONTE

IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia

DATA DE PUBLICAÇÃO

07/10/2011

RESUMO

HIV-1 genetic variability is a wellkown problem that makes diagnosis and treatment difficult to manage. Also, this variability is a problem for trasmission, disease progression and for the development of vaccines, being important to know the subtypes presented in each population worldwilde and in Brazil to provide more effective treatment. The present study have the aim to describe the subtype prevalent in Piauà state, the resistance profile of thouse to antiviral treatment, laboratory exams and the epidemiologic point of view of HIV-1 in PiauÃ. Samples of blood from 60 patients (HIV-1 positive) were colect at Central Public Laboratory in Teresina/PI, from maio to april 2009. Proviral DNA were isolated and Nested PCR were performed for two genomic regions (pro e tr), being sequenced 37 samples. Analysis to the segment for gene pro, 32 (86,5%) were subtype B and 2 (5,4%) subtype D. For tr segment all samples were subtype B (20). Statistics analysis found a significant association between vÃrus subtype and drug users, blood transfusion and STD (p <0,05). Furthermore, the study reveal that even with two subtypes of HIV-1 detected (B e D), a low prevalence of drug resistance was observed to the protease inhibitors (PI) (2,9%; 1/34), nucleosidic reverse transcriptase inhibitor (NRTI) (15%; 3/20) and non nucleosidic (NNRTI) (10%; 2/20).

ASSUNTO(S)

farmacologia hiv subtipos variaÃÃo genÃtica resistÃncia aos arv epidemiologia do hiv-1 piauÃ/brasil hiv subtypes genetic variability drug resistance piauÃ/brazil epideiologyof hiv-1

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