Preparação e caracterização de lipossomas elasticos e elastico-magneticos para administração transdermica de moleculas bioativas / Preparation and characterization of elastic and elastic-magnetic liposomes for transdermal transport of drugs

AUTOR(ES)

Raquel de Melo Barbosa

DATA DE PUBLICAÇÃO

2005

RESUMO

The purpose of this work was to study the preparation and characterization of elastic and elastic-magnetic liposomes designed to facilitate the transdermal transport of drugs. The prepared liposomes were unilamellar, composed by synthetic dymirystoylphosphatidylcholine (DMPC), hydrogenated soy phosphatidylcholine or egg phosphatidylcholine (PCegg) as structural components and by the derivative lauric acid surfactants: ?C IND. 12??E IND. 5?(polyoxyethylene-5-lauryl ether), PEG4L (polyethyleneglycol-4-lauryl ester), PEG4DL (polyethylenoglycol-4 dilauryl ester), PEG8L (polyethyleneglycol-8-lauryl ester) e PEG8DL polyethyleneglycol-8- dilauryl ester) as elastic components. Magnetic properties were added to elastic liposomes by incorporation of colloidal magnetite. The incorporation of surfactants to liposomes was done by two procedures: during hydration of lipid film or by incubation with preformed liposomes. The elastic liposomes were characterized through their phospholipid contents, mean diameter and size distribution, incorporation of surfactants, capability for permeation through artificial membranes containing 50 or 30 nm porous, elasticity and storage stability. The incorporation of colloidal magnetite was also characterized in elastic-magnetic liposomes. The experimental results show that the phospholipid phase transition temperature, the fluidity of the lipid bilayer generated by surfactant incorporation and the preservation of particle integrity were factors determining the performance of elastic liposomes on permeation through nanoporous membranes. In this context, DMPC and PCegg phospholipids and the surfactants PEG8L and PEG8DL were the best compounds... Note: The complete abstract is available with the full electronic digital thesis or dissertations

ASSUNTO(S)

lipossomos surface active agents agentes ativos de superficie liposomes medicação transcutanea transdermal medication

Documentos Relacionados

• Rheology and transition shapes of elastic liposomes in nanopores membranes
• Preparação, caracterização de lipossomas e microesferas para aplicação na terapia por dessensibilização de reação alergica
• Rhodium(II) citrate: synthesis, characterization, adsorption on maghemita nanoparticles, and preparation magnetic fluids
• Citrato de ródio(II): síntese, caracterização, adsorção em nanopartículas de maghemita e preparação de fluidos magnéticos
• Preparação e caracterização de lipossomas para a administração por inalação de compostos terapeuticos utilizados na terapia da tuberculose