Paradoxical psoriasis after the use of anti-TNF in a patient with rheumatoid arthritis

AUTOR(ES)

Vasconcellos, Jaqueline Barbeito de, Pereira, Daniele do Nascimento, Vargas, Thiago Jeunon de Sousa, Levy, Roger Abramino, Pinheiro, Geraldo da Rocha Castelar, Cursi, Ígor Brum

FONTE

An. Bras. Dermatol.

DATA DE PUBLICAÇÃO

2016-10

RESUMO

Abstract The use of tumor necrosis factor antagonists (anti-TNF) has become a usual practice to treat various inflammatory diseases. Although indicated for the treatment of psoriasis, anti-TNF may paradoxically trigger a psoriasiform condition. We present a case of a female patient who, during the use of infliximab for rheumatoid arthritis, developed psoriasis. In an attempt to switch anti-TNF class, we observed a cumulative worsening of the lesions requiring suspension of the immunobiological agent and the introduction of other drugs for clinical control. The therapeutic challenge of this paradoxical form of psoriasis is the focus of our discussion. The use of another anti-TNF in these patients is a matter of debate among experts.

Documentos Relacionados

• Interstitial lung disease due to anti-TNF use in the treatment of psoriasis
• Cutaneous histoplasmosis as a complication after anti-TNF use - Case report
• The efficacy of anti‐TNF in rheumatoid arthritis, a comparison between randomised controlled trials and clinical practice
• Modulation of lipoprotein plasma concentrations during long‐term anti‐TNF therapy in patients with active rheumatoid arthritis
• Expression of lymphatic markers and lymphatic growth factors in psoriasis before and after anti-TNF treatment