Obesity and insulin resistance: molecular, biochemical and ultra-structural adaptations. / Obesidade e resistência à ação da insulina: alterações moleculares, bioquímicas e estruturais.

AUTOR(ES)

Luciana Oquendo Pereira Lancha

DATA DE PUBLICAÇÃO

2009

RESUMO

The possible causes of increased mortality and morbidity associated with obesity have been focused by many studies that attempt to understand the metabolic syndrome, characterized by various metabolic disorders such as insulin resistance, hypertension and dyslipidemia. Thus, the aim of this study was to verify the possible mechanisms responsible for developing glucose intolerance after a high fat diet intake in healthy female rats. Female Wistar rats were fed either with high fat diet or with the control diet for several weeks. The rats fed with a high fat diet for 60 days presented impaired Glut 4 and insulin receptor gene expression. High fat diet promoted a reduced activity of hexokinase and increased activity of citrate synthase, aspartate aminotransferase and BCAA transaminase, indicating an adaptation in the metabolic pathway, with increase activity of Krebs cycle and increased usage of amino acids in anaplerotic reactions.

ASSUNTO(S)

bioquímica celular cell ultra-structure obesity glucose intolerance insulina ((resistência) intolerância à glicose ultraestrutura celular cell biochemistry dieta hiperlipídica high fat diet insulin (resistance) obesidade

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