Obesidade e câncer de tiróide : em busca de uma ligação / Obesity and cancer thyroid : in search of a connection
AUTOR(ES)
Aline Castaldi Sampaio
DATA DE PUBLICAÇÃO
2011
RESUMO
Obesity is a complex, multifactorial disease that develops from the interaction between genotype and environment. It may be defined as a syndrome characterized by an increase in body fat storage and its prevalence has increased dramatically in industrialized and developing nations. There are several reasons for medical concern regarding overweight and obesity. It increases the risk for several diseases, especially cardiovascular diseases, type 2 Diabetes Mellitus and hypertension. Collect weight, height and blood of 141 patients with DTC (126 women and 15 men) with 126 carefully matched control subjects (89 women and 37 men) for age, other morbid conditions, smoking, alcohol consumption, physical activity, among others. All 267 subjects underwent a medical history questionnaire that included food and collection of peripheral blood for genotyping .by .PCR-RFLP. The evaluation of food showed that both patients and controls, had a diet rich in fats and sugars, with insufficient fiber content, fruits and vegetables and insufficient physical activity performed. Overweight was more frequent among patients with DTC (60.28%) than in the control group (40.06%) increased risk of developing cancer in obese subjects (OR= 3.787 ;IC95% 2.115;6.814; p= <.0001) Excess weight increases the risk of CDT among women almost two times (OR = 1.925, IC95% 1.110 a 3.338; p = 0.0259). However, among men, being overweight did not represent risk for the development of CDT (OR = 2.110, IC95% 0.6237 a 7.137;p=0.3498). There was no correlation between the genetic profile of IRS-1 gene in the population studied, and for genotyping the gene mutation PPARy2 appears more prevalent in cases increased the risk for developing thyroid cancer (OR= 3.738 ; IC = 1.151;12.139; p= 0.0282). A multiple logistic regression analysis showed that obesity (p= <.0001) and the inheritance of the polymorphism of PPARy in heterozygous (p = 0.0282) were factors associated with risk of thyroid cancer. In conclusion, our data indicate that excess weight contributes to an increased risk for DTC, which may contribute to the relatively larger increase observed in females and suggest that the implementation of prevention policies in public health, particularly for people at risk, could also decrease the prevalence of CDT in the Brazilian population
ASSUNTO(S)
obesidade gene cancer tireóide obesity gene cancer thyroid
