Meloxicam and melatonin: did they trigger a synergic action during the acute phase of the experimental infection with Trypanosoma cruzi? / Meloxicam e melatonina: teriam uma ação sinérgica durante a fase aguda da infecção experimental por Trypanosoma cruzi?

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

The modulation of the immune responses in experimental models infected with Trypanosoma cruzi has effectively contributed for the investigations of new therapies used to treat Chagas disease. In this study, it was evaluated the production of Th1 and Th2 cytokines, which play a role during the acute phase of the disease, as well as prostaglandin E2 and nitrite, number of blood parasites and cardiac tissue parasitism in male Wistar rats infected with the Y strain of T. cruzi. Experiments were performed on 7, 14 and 21 days after infection in which Th1 cytokines such IL-2, IFN-, TNF- were done and Th2 cytokines as IL-4 and IL-10. The parameters were evaluated with/without the administration of meloxicam, melatonin or both. Melatonin contributed for the hosts protection in animals experimentally infected with T. cruzi through its immunomodulator actions. The blockage of PGE2 synthesis was attributed to the administration of meloxicam and/or melatonin during the acute phase of infection, followed by a modulation of the Th1 and Th2 cytokines. In this work enhanced levels of IFN-, IL-2 and NO were observed. The analysis of these data was beneficial for the hosts protection through a reduced number of amastigote nests in heart tissue. These results permit to establish alternative mechanisms to treat the acute chagasic infection through a better understanding of the immune responses against T cruzi.

ASSUNTO(S)

melatonina citocinas prostaglandina e2 t. cruzi imunossupressão melatonin meloxicam trypanosoma cruzi meloxicam cytokines prostaglandin e2

ACESSO AO ARTIGO

Documentos Relacionados