Mechanism of ethanol inhibition of fermentation in Zymomonas mobilis CP4.
AUTOR(ES)
Osman, Y A
RESUMO
Accumulation of alcohol during fermentation is accompanied by a progressive decrease in the rate of sugar conversion to ethanol. In this study, we provided evidence that inhibition of fermentation by ethanol can be attributed to an indirect effect of ethanol on the enzymes of glycolysis involving the plasma membrane. Ethanol decreased the effectiveness of the plasma membrane as a semipermeable barrier, allowing leakage of essential cofactors and coenzymes. This leakage of cofactors and coenzymes, coupled with possible additional leakage of intermediary metabolites en route to ethanol formation, is sufficient to explain the inhibitory effects of ethanol on fermentation in Zymomonas mobilis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=214226Documentos Relacionados
- Sugar cane juice fermentation by Zymomonas mobilis CP4 subjected to inhibition by ethanol and high initial concentration of substrate
- Mechanism of glutamate uptake in Zymomonas mobilis.
- Ethanolic fermentation in transgenic tobacco expressing Zymomonas mobilis pyruvate decarboxylase.
- Lipid composition of Zymomonas mobilis: effects of ethanol and glucose.
- Produção de glutaminase por Zymomonas mobilis cp4 na fermentação de glicose utilizando ferramentas estatísticas