Lupus eritematoso sistÃmico: caracterÃsticas clÃnico-epidemiolÃgicas de 151 pacientes acompanhados em uma clÃnica privada de Recife/PE no perÃodo de 1963 a 1997.

AUTOR(ES)

AndrÃa DÃria Batista

DATA DE PUBLICAÇÃO

2003

RESUMO

The aim of this study was to describe and compare the clinical and epidemiological features of 151 systhemic lupus erythematosus (SLE) patients followed in a private clinic between 1963 and 1997 in Recife (state of Pernambuco). All the patients met the American College of Rheumatology (ACR) criteria for SLE. We analyzed retrospectively the clinical, laboratorial and epidemiological features of the patients. Thirty-two patients were diagnosed between 1963 and 1981 (group I) and one hundred and nineteen were diagnosed between 1982 and 1997 (group II). For the statistic analysis the qui square test was used. The considered significant level was p<0.05. One hundred and thirty eight patients (91,4%) were female and one hundred and forty three (94,7%) were white. The mean age at the beginning of follow-up was 30 year-old (9-55 year-old). Osteoarticular and cutaneos symptoms were the most frequent clinical manifestations (94.7% and 91.4%). The group II presented with more osteoarticular (p=0.04) and cutaneous (p=0.021) symptoms and the group I with more cardiac symptoms (p=0.008), hipoalbuminemia (p=0.00), hipergamaglobulinemia (p=0.005), granulosus casts (p=0.00) and LE cell (p=0.00). Seventy one percent of pregnancies had good fetal outcome. The obstretic complications were more frequent in grupo I (p=0.022). It was observed a better outcome in group II patients, with mortality rate of 46,9% for group I and 10,1% for group II (p=0,00). This difference remained even after diseaseâs duration control. The results showed that SLE patients followed between 1982-1997 presented with less severe disease and that the disease had a tendency to diminish the mortality during the years. This better outcome may be related with earlier diagnosis and better treatment

ASSUNTO(S)

lupus eritematoso sistÃmico casos clÃnicos medicina

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