Perfil lipÃdico de pacientes com Lupus Eritematoso SistÃmico em um Hospital UniversitÃrio

AUTOR(ES)
DATA DE PUBLICAÇÃO

2003

RESUMO

The blood lipid abnormalities, one of the risk factors for the development of atherosclerosis, is often observed in Systemic Lupus Erythematosus (SLE) and many factors are involved for the lipid alteration in this disease. The main purpose of this study was to identify a lipid profile in SLE patients and also to estimate the influence of clinical characteristics like body mass index (BMI), systemic hypertension, disease s activity and duration as well as the use of corticosteroids and antimalarials (AM) on it. The inclusion criteria were patients with SLE diagnosed according to established by the American College of Rheumatology (ACR): fulfilled four or more itens of the ACR classification criteria, and age betweeen 16 and 55 years. The exclusion criteria were: obesity, diabetes mellitus, chronic renal failure, nephrotic syndrome, menopause, hypothyroidism, pregnancy and the use of contraceptives hormone. Forty-two patients with SLE had the lipid profile done after 12 hours of fasting. It was analysed total cholesterol (TC), triglycerides (TG), high-density lipoprotein C (HDL-C), low-de nsitty lipoprotein C (LDL-C), quilomicrons (QM), lipoproteins fenotyping and apoliprotein A in 42 patients with SLE, being 36 woman (85,7%) and six men (14,3%),with a mean age of 30,4 years (17 to 48 years) and a mean of 53 months of disease duration (02 to 144 months). The body mass index (BMI) was 29,58 kg/m2 and 08 patients had hypertension (19,1%). The ACR classification criteria ranged from 4 to 9 itens with a mean of 5,6 and 15 patients (35,7%) showed disease activity measured by SLEDAI. For the statistical analysis, absolut and percentile distributions and statistical measures had been gotten of the numerical variable, using the t-Student or Mann-Whitney tests for the variable with two categories and the F(ANOYA) or Kruskal-Waliis for the variable with three categories. The considered significant level was 5,0%. High level of total cholesterol was observed in 45 %, LDL-C in 38,1%and triglycerides in 30,9% of the patients. The disease activity showed siginificant effect in the rise of TG levels (p=0,0346); patients on steroids above 20 mg/day showed high level of CT (p=O,O376),TG(p=O,OO2a8n) dTL (p=O,O15)The use time of steroids and the use of AM didn t show significant effect on the lipid profile in this patients. The result showed that SLE patients at HC-UFPE had abnormalities on the lipid profile characterized by high levels of TC, LDL and TG. Steroids in high dose were the main factor in this lipid alteration. Neither disease nor corticosteroid duration interfered with the lipid profile. SLE activity only modulate the TG level. There. was no significant effect of AM on lipid profile in this study

ASSUNTO(S)

lipid profile medicina systemic lupus erythematosus dislipidemia aterosclerose lupus eritematoso sistÃmico atherosclerosis

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