Importance of oxaloacetate synthesis on endurance exercise rats: effects of aspartate, asparagine and carnitine supplementation / Papel da geração de oxaloacetato no exercício físico moderado em ratos: consequências da suplementação de aspartato, asparagina e carnitina

AUTOR(ES)
DATA DE PUBLICAÇÃO

1993

RESUMO

The importance of oxaloacetate formation was investigated by measuring pyruvate carboxylase activity in muscles and by given its precursors (aspartate, asparagine) in the diet of rats. The activity of pyruvate carboxylase markedly raised during physical effort and so might provide oxaloacetate for Krebs cycle functioning. The supplementation of aspartate and aspagine for a prolonged period of time (5 weeks) promotes increment in the resistance to exercise in rats trained to swimming during 1 hour daily for 5 weeks. This effect is accompanied by an increase in the size and number of mitochondria and also changes in glucose metabolism; elevation in glycogen synthesis and content and reduction in the rate of glycolysis. These results suggest that the production of oxaloacetate plays a role to maintain the moderate exercise during a prolonged period of time. Nevertheless, the aspartate and asparagine supplemented in the diet, despite improving the perfomance to moderate and prolonged exercise, provokes muscle ultraestructure lesions of mitochondria, "Z" line and miofibrils.

ASSUNTO(S)

carnitine exercises aspartate exercícios asparagina asparagine aspartato carnitina

ACESSO AO ARTIGO

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