Asparagine
Mostrando 1-12 de 987 artigos, teses e dissertações.
-
1. Asparaginase: an old drug with new questions
ABSTRACT The long-term outcome of acute lymphoblastic leukemia has improved dramatically due to the development of more effective treatment strategies. L-asparaginase (ASNase) is one of the main drugs used and causes death of leukemic cells by systematically depleting the non-essential amino acid asparagine. Three main types of ASNase have been used so far:
Hematol., Transfus. Cell Ther.. Publicado em: 2020-09
-
2. PEG-asparaginase and native Escherichia coli L-asparaginase in acute lymphoblastic leukemia in children and adolescents: a systematic review
Abstract Introduction Acute lymphoblastic leukemia (ALL) is the cancer with the highest incidence in childhood and adolescence, and pharmacotherapy is the primary form of treatment. Objective and methods A systematic review of the efficacy and safety of polyethylene glycol (PEG)-asparaginase in acute lymphoblastic leukemia therapy in children and adolescen
Hematol., Transfus. Cell Ther.. Publicado em: 2020-03
-
3. Mutational landscape of head and neck squamous cell carcinomas in a South Asian population
Abstract Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer type globally and contributes significantly to burden of disease in South Asia. In Pakistan, HNSCC is among the most commonly diagnosed cancer in males and females. The increasing regional burden of HNSCC along with a unique set of risk factors merited a deeper investigati
Genet. Mol. Biol.. Publicado em: 14/11/2019
-
4. An Appraisal on the Source-to-Sink Relationship in Plants: an Application of Desorption Electrospray Ionization Mass Spectrometry Imaging
Amino acids/ureides and carbohydrates are the main nutrients for the plants growth. These metabolites are continuously translocated through the plant organism via well-known transportation mechanisms. The well-established source-to-sink relationship involves the transfer of these nutrients from mature (source) to young (sink) leaves. Desorption electrospray
J. Braz. Chem. Soc.. Publicado em: 2018-01
-
5. Current applications and different approaches for microbial L-asparaginase production
ABSTRACT L-asparaginase (EC 3.5.1.1) is an enzyme that catalysis mainly the asparagine hydrolysis in L-aspartic acid and ammonium. This enzyme is presented in different organisms, such as microorganisms, vegetal, and some animals, including certain rodent's serum, but not unveiled in humans. It can be used as important chemotherapeutic agent for the treatmen
Braz. J. Microbiol.. Publicado em: 2016-12
-
6. The physiological and biochemical mechanism of nitrate-nitrogen removal by water hyacinth from agriculture eutrophic wastewater
ABSTRACT Large amount of agriculturl wastewater containing high level nitrate-nitrogen (NO3 --N) is produced from modern intensive agricultural production management due to the excessive use of chemical fertilizers and livestock scale farming. The hydroponic experiment of water hyacinth was conducted for analyzing the content of NO3 --N, soluble sugar conten
Braz. arch. biol. technol.. Publicado em: 20/10/2016
-
7. Luminescent Terbium Doped Aluminate Particles: Properties and Surface Modification with Asparagine
New luminescent organic-inorganic hybrid particles based on Tb-doped aluminates and asparagine (Asn) surface modifiers were investigated. The Tb3+ doped inorganic core was obtained by spray pyrolysis, at 200 ºC γ-AlOOH (BOE:Tbx%) or at 700 ºC γ-Al2O3 (γTA:Tbx%). The reaction of Asn with boehmite in water disaggregated the sub-micronic boehmite particles
J. Braz. Chem. Soc.. Publicado em: 2015-12
-
8. Kinetic properties of Streptomyces canarius L- Glutaminase and its anticancer efficiency
Abstract L-glutaminase was produced by Streptomyces canarius FR (KC460654) with an apparent molecular mass of 44 kDa. It has 17.9 purification fold with a final specific activity 132.2 U/mg proteins and 28% yield recovery. The purified L-glutaminase showed a maximal activity against L-glutamine when incubated at pH 8.0 at 40 °C for 30 min. It maintained its
Braz. J. Microbiol.. Publicado em: 09/10/2015
-
9. Thermodynamic study of asparagine and glycyl-asparagine using computational methods
This work aimed to develop an ab initio procedure for accurately calculating pKa values and applied it to study the acidity of asparagine and glycyl-asparagine. DFT methods with B3LYP composed by 6-31+G(d) basis set were applied for calculating the acidic dissociation constant of asparagine and glycyl-asparagine. The formation of intermolecular hydrogen bond
Braz. arch. biol. technol.. Publicado em: 2015-06
-
10. Nano-Detoxification of Organophosphate Agents by PAMAM Derivatives
For the first time, the adsorption of pesticides such as azinphos-methyl and methamidophos by polyamidoamine (PAMAM) derivatives was studied. Amine groups of PAMAM (G4 and G5) were functionalized with different biomolecules such as folic acid, coumarine, arginine, lysine, and asparagine. Subsequently, the synthesized compounds were used to trap organophospha
J. Braz. Chem. Soc.. Publicado em: 2015-03
-
11. Mass spore production and inoculation of Calonectria pteridis on Eucalyptus spp. under different environmental conditions
Calonectria pteridis is one of the most important causal agents of Calonectria leaf blight (CLB) of Eucalyptus spp. in Brazil, which is a limiting factor for growth of Eucalyptus plantations. In this study we developed standard procedures for in vitro mass spore production and inoculation of C. pteridis for screening plant species and clones for resistance t
Trop. plant pathol.. Publicado em: 2013-10
-
12. Fox grape cv. Bordô (Vitis labrusca L.) and grapevine cv. Chardonnay (Vitis vinifera L.) cultivated in vitro under different carbohydrates, amino acids and 6-Benzylaminopurine levels
The aim of this work was to study the influence of sucrose and glucose, amino acids and BAP (6-Benzylaminopurine) levels on in vitro shoot regeneration of fox grape cv. Bordô and grapevine cv. Chardonnay. The nodal segments from micropropagated material were used as explants and half-strength MS medium as the basal medium. Sucrose and glucose at 15, 30 and
Braz. arch. biol. technol.. Publicado em: 2013-04