Hepatic alterations in severely obese patients: clinical-laboratory and histopatological evaluations before surgical treatment of obesity / "Alterações hepáticas em grandes obesos: avaliações clínico-laboratoriais e histopatológicas antes do tratamento cirúrgico da obesidade"

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) has been associated with obesity. Determine prevalence of NAFLD/NASH and metabolic syndrome (MS) in severe obesity; define clinical predictor of steatohepatitis; establish histological criteria necessary to diagnose NASH. Evaluation of 325 patients submitted to bariatric surgery (BMI = 35 kg/m2), among which 146 were submitted to histological analysis; variables clinical and biochemical were analyzed and correlated to histological characteristics. NAFLD occurred in 111 (76%) patients and NASH, according to histological criteria used, in 25.3% to 55.5%; MS was present in 57.2%. Predictors of NASH: MS; glycaemic alterations; hypertriglyceridaemia and high blood pressure (HBP). Predictors of fibrosis: age above 30 years and high AST

ASSUNTO(S)

fígado/patologia insulin resistance fígado/anatomia &histologia fatty liver fígado gorduroso obesity/surgery síndrome x metabólica liver/anatomy &histology obesidade metabolic syndrome x resistência à insulina obesidade/cirurgia liver/pathology obesity

ACESSO AO ARTIGO

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