Food intake assessesment and nutritional status of low mineral density climacteric women. Hidrolyzed collagen dietary supplementation effect on bone metabolism / Avaliação dietetica e nutricional de mulheres na pos-menopausa com baixa densidade mineral ossea. Efeito no metabolismo osseo da suplementação dietetica com hidrolisado de colageno

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

Objectives: Evaluate the potential effect of hydrolyzed collagen, as a dietetic supplement, in the treatment of osteopenic postmenopausal women and to study of the anthropometric and food intake characteristics of the group. Methods: a randomized double-blind clinical assay with osteopenic postmenopausal women, was planned. The volunteers ingested 10 g/day of hydrolyzed collagen or a placebo for a period of 24 weeks. Calcium, phosphate, alkaline phosphatase, serum creatinine, 24h urinary calcium, the bone resorption marker carboxy-terminal collagen crosslinks (CTX) and the bone formation markers (osteocalcine and bone-specific alkaline phosphatase) were determined at the beginning and at 12 and 24 weeks of treatment. The intakes of nutrients and energy were estimated using the 24h record and a food frequency questionnaire using the Brazilian Food Composition Table (TACO) as reference. Results were analyzed using the SAS (MANOVA) and the Pearson?s correlations were determined between variables, adopting 5% as a level of significance. Results: The sample was constituted of 35 placebo and 36 treated subjects (mean age 57.3 ± 4.8 years and BMI of 27,4 ± 4,5 kg/m2). Of those subjects belonging to the treated group that complained from articular or bone pains, 34% reported the cessation of the symptom by the end of the study. The analysis of variance revealed no significant effect of the dietary supplement on bone metabolism. No Pearson?s correlations were found between the set of variables (age, nutrient intake, BMI, mineral density) and markers of bone metabolism, at either one of the times. Forty-two percent of the patients were overweight and 26% obese. Excess of lipids in the diet was observed in 38% of the women and 22% exceeded the recommendations for saturated fat. Cholesterol uptake was 222 ± 98 mg. The mean intake of calcium was 654 ± 358 g/day and 94% failed to reach the adequacy intake. Conclusions: Under the conditions of this intervention consumption of the hydrolyzed collagen did not produce any observable effects in bone metabolism as measured by currently accepted markers of bone resorption or formation. Most of the patients exhibited inadequacy in calcium intake as well as excessive body weight

ASSUNTO(S)

osteoporosis pos-menopausa post-bone biochemical markers collagen nutrient adequacy colageno osteoporose dieta adequação de nutrientes diet marcadores bioquimicos osseos

ACESSO AO ARTIGO

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