Evaluation of chitosan/tricalcium phosphate sponge utilization in rat calvarial bony defects repair / Avaliação da utilização de esponja de chitosan/tricalcio fosfato no reparo de defeitos osseos em calvaria de ratos
AUTOR(ES)
Saulo Cabral dos Santos
DATA DE PUBLICAÇÃO
2007
RESUMO
Periodontology great challenge is to aim the regeneration of periodontal apparatus previously exposed to periodontal disease. Bone substitutes have been extensively tested and used to obtain regeneration. Despite autogenous bone has been considered the gold standard material to perform these techniques there are some restrictions which limit its use. The objective of this study is to evaluate the chitosan/tricalcium phosphate sponge, a non-toxic natural and biodegradable biopolymer, in calvarian defects repair. Twenty adult male Wistar rats were used in this research. Two critical defects were prepared on the parietal bone of each animal using a trephine bur of 5mm inside diameter. One of the defects received chitosan sponge as treatment (test group) and the other was treated with particulate autogenous bone (positive control group). After 60 days the animals were sacrificed and the histological sections were obtained. It was observed in test group a mean remaining chitosan sponge of 37,79%. A linear analysis showed a 0,57±0,38 bone fulfilling mean of the test defects. In defects treated with autogenous bone (positive control group) the mean bone vital observed was 5,02mm. In percentual terms the defect bone fulfilling was less observed in test group rather than control group (7,72% and 68,75% respectively, Tukey test p<0,001). Chitosan/tricalcium phosphate sponge does not improve bone repair in rats calvarian defects
ASSUNTO(S)
biomateriais chitosan biomaterials quitosana ossos - regeneração bone regeneration
ACESSO AO ARTIGO
http://libdigi.unicamp.br/document/?code=vtls000424110Documentos Relacionados
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