Estudos da Redução Assimétrica de Iminas e Chalconas : Síntese de Compostos com Potencial Ação Farmacológica/Tecnológica

AUTOR(ES)

Wender Alves Takada da Silva

DATA DE PUBLICAÇÃO

2009

RESUMO

Chalcones are defined as α,β-unsaturated ketones in which both the carbonyl and the olefinic fragment are linked to an aromatic ring. They possess a large spectrum of action, such as anti-inflammatory and antioxidant activity in vitro and in vivo. This raises interest in synthesizing and characterizing different chalcones, in order to obtain molecules or precursors in the synthesis of pharmacologically active molecules. Thus, reductions (racemic and asymmetric) of these compounds were studied, using methodologies developed in our work group and comparing with Noyori`s method, to obtain raw materials that were used in the synthesis of more complex molecules. Another study realized was the development and application of new methodologies in the asymmetric reduction of imines. The methods were based on the supramolecular chemistry (β-cyclodextrin) and on Noyoris method to compare the yields, and primarily, the enantiomeric excesses. With the good results achieved, the formal synthesis of two indolizidinic compounds ((+)- Harmicine and (+)- Deplancheine) and the total synthesis of (-)-Quinolactacin B were achieved, all of which show pharmacological action.

ASSUNTO(S)

quimica chalconas imunossupressores redução assimétrica

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