Estudo quÃmico e de atividade biolÃgica da Spigelia flemmingiana

AUTOR(ES)
DATA DE PUBLICAÇÃO

2002

RESUMO

Brazil presents a wide variety of superior plants, which have not been yet studied. Among these plants, we may find Spigellia flemmingiana, from the family Loganeaceae, which is currently utilized for anti-helmintic treatment. In the present work, the chemical constituents, antimicrobial and anti-helmintic activities were studied using the crude extracts prepared from this plant with the solvents ethanol, cyclohexane and ethyl acetate. With regard to the antimicrobial activity, this was tested through the agar diffusion method using the following test microorganisms: Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Candida albicans, Candida lypolytica and Candida parakrusei. Besides, the anti-helmintic activity was evaluated through the direct inhibition of eggs eclosion of Haemonchus contortus in solution with the plant extracts. The antimicrobial activity tests demonstrated that none of the crude extracts inhibited the growth of the utilized microorganisms. Nevertheless, the cyclohexane and ethyl acetate extracts demonstrated anti-helmintic activity on the tests against Haemonchus contortus. These extracts were purified for the isolation and structure determination of the possible compounds responsible for the biological activity. From the cyclohexane extract was isolated a compound named SFH-1 and from the ethyl acetate extract, the compound SFA-2. The present study proved the utilization of Spigelia flemmingina as anti-helmintic. Spectroscopic analysis identified the compound SFH-1 as being β-sitosterol and the SFA-2 as a benzoic acid derivative, the Vanilic acid

ASSUNTO(S)

anti-helmÃntica famÃlia loganeaceae quimica dos produtos naturais constituintes quÃmicos spigellia flemmingiana atividade antimicrobiana

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