Estudo histoquimico e imuno-histoquimico da endocervice para diagnostico diferencial entre metaplasia tubaria e adenocarcinoma in situ

AUTOR(ES)
DATA DE PUBLICAÇÃO

1995

RESUMO

Endocervical tubal metaplasia, a benign lesion, is known to be frequently misdiagnosed as adenocarcinoma in situ. Its correct identification is needed in order to avoid inadequate managements. We selected 18 cases of endocervical tubal metaplasia and 16 of adenocarcinoma in situ. Only specimens that had morphologic appearences typical for either tubal metaplasia or adenocarcinoma in situ were chosen. All cases were analysed by hematoxilin-eosin, stains for mucin, Alcian blue pH 2.5, mucicarmine, PAS and PAS diastase, and submitted to immunoperoxidase reaction for carcinoembryonic antigen and vimentin. Statistical analysis demonstrated no signifficant difference in the reactions for mucins between the lesions. Whereas CEA was more frequently positive in AIS than in TM cases, VIM was negative in all cases of AIS and positive in 78% of TM cases and was therefore considered more useful for the differential diagnosis

ASSUNTO(S)

colo uterino adenocarcinoma metaplasia carcinoma in situ imunohistoquimica

ACESSO AO ARTIGO

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