Estudo comparativo in vitroentre preparações de imunoglobulina G, para uso intravenoso, obtidas de plasma humano de variadas procedências e processadas por diferentes técnicas de separação / "In vitro" comparative study between imunoglobulin G preparations, intravenous use, human plasma derived from different plasma sources and different separation techniques

AUTOR(ES)
DATA DE PUBLICAÇÃO

2001

RESUMO

A family of glicoproteins, which are called antibodies or immunoglobulins (IgG), mediates the protective effects of humoral immunity. In Brazil, the IgG for intravenous use are imported from other countries. The first Brazilian immunoglobulin G for therapheutic use was obtained from human plasma at the Fundação Pró-Sangue Hemocentro de São Paulo. The present study was carried out to evaluate different preparations of IgG, human plasmad-derived, include the preparation from Brazil. The protein concentration, IgG subclass distribution, specific antibody activities and safety regarding the main blood transmitted infectious diseases were analyzed. In some preparations, IgG protein concentration and subclass distribution were different from their specifications. Some preparations showed specific antibody activity against the following antigens: A and B hepatitis virus, rubella, herpes simplex virus, citomegalovirus, measles virus, Streptococcus pyogenes β-hemolytic group A and Toxoplasma gondii. The presence of antibodies against antigens such as HTLV I/II, HAV, HBV, HCV and Treponema pallidum has compromissed the quality guaranty of the material-source (plasma) used in some preparations. This study has also showed that a complete and effective program for the quality evaluation of IgG preparations used in Brazil is needed and should be urgently established

ASSUNTO(S)

hematology subclasses de igg eficácia e segurança de preparações de igg imunoterapia techniques to purify immunoglobulin g plasma (aplicações terapêuticas) effectiveness and safety of igg preparations preparações de igg antibodies activity igg preparations quality control igg preparations hematologia medicamento (análise) igg subclasses preparations igg atividade de anticorpos das preparações de igg controle de qualidade de imunoglobulinas g immunotherapy métodos de purificação de imunoglobulinas g

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