Estudo comparativo do efeito do diclofenato potassico e piroxicam, sobre as transaminases, soro de ratos parcialmente hepatectomizados

AUTOR(ES)
DATA DE PUBLICAÇÃO

1992

RESUMO

The purpose of this work was to evaluate the influence os potassium diclofenac (Cataflam "MARCA REGISTRADA ) and piroxicam (Feldene MARCA REGISTRADA ) in rat liver regeneration. The methods for a 70 % hepatectomy were the same as those described by HIGGINS and ANDERSON (1931). Thirty male rats (Rattus novergicus albinus, Wistar) sixthy days old were distributed as follows: 1th Group (D) - treated with 1,5 mg/kg/day diclofenac (I.P.); 2th Group (P) - treated with 0,5 mg/kg/day piroxicam (I.P.); 3 ths Group (C) - control group with animal received NaCl 0,9 % (I.P.). The serum concentration of aspartate aminotransferase (TGO) and alanine aminotranferase (TGP) were measured in time intervals of zero, 24, 48 hours, 7 and 14 days. The results showed that potassium diclofenac increased the plasma level of TGO in time zero in relation to piroxicam and control (p<0.05); TGO and TGP in time 48 hours in relation to control (p>0.05); TGP in time 48 hours in relation to piroxicam (p<0.05); TGP in time 14 days in relations to control (p<0.05)

ASSUNTO(S)

agentes antiinflamatorios transaminase glutamico oxalacetica figado rato como animal de laboratorio

ACESSO AO ARTIGO

Documentos Relacionados