Efeito de antagonistas de receptores H1, e H2, sobre a Y-glutamiltransferase, no soro de ratos parcialmente hepatectonizados

AUTOR(ES)

Vitoldo Antonio Kozlowski Junior

DATA DE PUBLICAÇÃO

1991

RESUMO

Adult male albino rats (Wistar strain) were used to investigate the effecte of selective antagonist of only peripheral histamine H1-receptors, Terfenadine and histamine H2-receptors antagonist, Cimetidine on the serum activity of the enzyme y-glutamiltransferase( γ-GT) during liver regeneration after partial hepatectomy. Sixty-seven animals were randomly divided into three groups and were sacrificed respectively, 6 h, 24 h and 360 h postoperatively. Each group was divided into four sub-groups that received doses of Terfenadine (2 mg/Kg,/day),Cimetidine (, 20 mg/Kg/day), Terfenadine (2mg /Kg /day) + Cimetidine (20 mg/Kg/ day) and NaCl 0,9 % (Control), intraperitoneally during the experimentation. The results obtained suggested that peri - pheral histamine Hl- receptor antagonist - Terfenadine, induced the 1(-glutamiltransferase serum activity in rats.360 h after partial hepatectomy.

ASSUNTO(S)

farmacologia dentaria

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