Effect of soluble factors produced by TLR-activated macrophages on T lymphocytes survival. / Influência da ativação de macrófagos via receptores do tipo Toll (TLRs) na produção de fatores moduladores da sobrevivência de linfócitos T.
AUTOR(ES)
Julia Cortina Campopiano
DATA DE PUBLICAÇÃO
2010
RESUMO
The interaction between innate and adaptative immunity occurs in several phases of the immune response. The Toll-like receptors (TLRs) have an important role in the activation of macrophages directly acting on the molecules secreted by these cells. Little is known about the role of these secreted molecules on the survival control of activated T lymphocytes (Activation-induced cell death - AICD). Therefore, the objective of the present work was to evaluate the effects of soluble factors produced by macrophages activated with several TLRs agonists, on the survival of T lymphocytes. First we sought the expression of TRLs on both bone marrow-derived and J774 macrophage cell line and we could see that both cells express all TLRs, except for TLR 11. The stimulation of both cells with TLRs agonists leads to the expression of NF-κB and the production of soluble factors that are able to protect DO11.10 T lymphocyte cell line from AICD, via down regulation of FasL partially mediated by PGE2.
ASSUNTO(S)
apoptosis toll-like receptors (tlrs) macrophages fas/fasl pamps t lymphocyte linfócitos t receptores do tipo toll (tlrs) apoptose macrófagos pamps fas/fasl
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