Papel dos receptores do tipo Toll na morte celular induzida por ativação (AICD) de linfócitos T. / Role of Toll-Like receptors in the activation-induced cell death (AICD) of T cells hybridoma.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

During an infection the number of T lymphocytes increases dramatically. The clonal expansion phase is followed by reducing the level of activated T cells that depends, in part, a process of cell death induced by activation (AICD). Our group showed that when APCs are stimulated with LPS, a TLR4 agonist, produce PGE2, which inhibits the AICD of CD4 + T cells by suppressing the expression of CD95L (Weinlich et al, 2008). However, the effects of direct stimulation of TLR on T cells on the process of AICD were little explained. Therefore, the project aims to determine whether the stimulation of different TLRs to their agonist is able to modulate AICD of T lymphocyte hybridoma DO11.10. Initially, we demonstrated that this hybridoma expresses TLR1, 2, 3, 4, 5, 6, 7, 9 and 11. Among all agonists used only imiquimod, a TLR7 agonist, reduced cell death when added during the induction of AICD. The protective effect of this agonist was by inhibiting the expression of CD95L, both at the mRNA and protein.

ASSUNTO(S)

toll-like receptors faz linfócitos t fasl t lymphocytes faz imiquimod imiquimod cell receptors receptores celulares apoptosis pathogen-associated molecular patern fasl receptores do tipo toll apoptose padrões moleculares associados à patógenos

ACESSO AO ARTIGO

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