Efeito da L-arginina na neoproliferação intimal e no remodelamento arterial após lesão por balão em ilíacas de coelhos hipercolesterolêmicos

AUTOR(ES)
DATA DE PUBLICAÇÃO

2005

RESUMO

Purpose: Neointimal proliferation and arterial remodeling are two of the most important factors responsible for restenosis. The purpose of this paper is to evaluate the influence of oral given L-arginine in neointimal proliferation and arterial remodeling after balloon injury in iliac arteries of hypercholesterolemic rabbits. Methods: 19 rabbits were divided in two groups: control group (GC) and arginine group (GA). In the first one, 19 arteries were studied and in the second 17 arteries were analyzed. Rabbit iliac arteries were submitted to a balloon angioplasty 15 days after the beginning of a 2% hypercholesterolemic feeding. Then, GA animals started to receive L-arginine orally in a 1 g/kg/day dose. Rabbits were sacrificed 15 days after the balloon lesion and their arteries were prepared for being microscopically analysed. To define the degree of neointimal proliferation we utilized the relation between the neointimal layer and the media layer of the artery. By other side, remodeling was defined as the relation between the medial portion of the artery (which had a greater degree of balloon lesion) and the lateral portions (which had a lower degree of balloon lesion). Results: Neointimal proliferation were 0,81510,2201 in the CG and 0,32960,1133 in AG. There were no statistic differences between arterial remodeling in both studied groups. Conclusion: In this experimental model, L-arginine reduced neointimal proliferation and did not change arterial remodeling in hypercholesterolemic rabbits.

ASSUNTO(S)

reestenose coronária angioplastia transluminal medicina

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