Cytokine profile associated with chronic and acute human schistosomiasis mansoni

AUTOR(ES)

Morais, Clarice Neuenschwander Lins de, Souza, Joelma Rodrigues de, Melo, Wlademir Gomes, Aroucha, Marcílio L, Miranda, Paulo, Domingues, Ana Lúcia Coutinho, Abath, Frederico Guilherme Coutinho, Montenegro, Silvia Maria Lucena

FONTE

Memórias do Instituto Oswaldo Cruz

DATA DE PUBLICAÇÃO

2008-09

RESUMO

The production and regulation of interleukin (IL) IL-13, IL-4 and interferon-gamma (IFN-³) was evaluated in 43 schistosomiasis patients with different clinical forms. Whole-blood cultures cytokine production in response to soluble egg antigen (SEA), soluble worm adult preparation (SWAP), mitogens, neutralizing antibodies or recombinant IL-13 were measured by ELISA. After SWAP stimulation, chronic patients, particularly hepatointestinals, produced higher levels of IL-4 in comparison with acute patients, suggesting the presence of a type 2 cytokine profile in these patients. Following SEA and SWAP stimulation, hepatosplenic (HS) patients showed increased levels of IFN-³ when compared with acute patients, indicating that HS disease in humans is associated with a type 1 cytokine response. The mechanisms of immune regulation are apparently different between the clinical stages of the disease, some of which are antigen-specific.

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