Complete genome of a dengue virus serotype 4 strain from Amazonas, Brazil
AUTOR(ES)
Nascimento, Valdinete Alves do, Souza, Victor Costa de, Naveca, Felipe Gomes
FONTE
Mem. Inst. Oswaldo Cruz
DATA DE PUBLICAÇÃO
02/02/2016
RESUMO
Dengue virus (DENV) infections represent a significant concern for public health worldwide, being considered as the most prevalent arthropod-borne virus regarding the number of reported cases. In this study, we report the complete genome sequencing of a DENV serotype 4 isolate, genotype II, obtained in the city of Manaus, directly from the serum sample, applying Ion Torrent sequencing technology. The use of a massive sequencing technology allowed the detection of two variable sites, one in the coding region for the viral envelope protein and the other in the nonstructural 1 coding region within viral populations.
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