Caracterização morfo-funcional da prostata de femeas do gerbilo Meriones unguiculatus e avaliação dos efeitos da testosterona sobre os componentes teciduais do orgão

AUTOR(ES)
DATA DE PUBLICAÇÃO

2002

RESUMO

The prostate is not an exclusive male organism, because it is also present in adults females of several rodents species and even in women. The female prostate has been considered homologous to the male ventral prostate, it is composed by sma1l clusters of glands and ducts intermixed to a musculofibrous matrix. It is known nowadays the fundamental importance of the better understanding of the physiological process that maintaÍfi this gland functiona1ly active in the female organism, once that it suffers the same diseases that compromises the male prostate during the climacteric. By this way, the goal of this study was to characterize histologica1ly, cytochemica1ly and ultrasttucturally the tissues components of normal and experimentally treated with testosterone female prostate of gerbil Meriones unguiculatus, during 21 days. In order to do this work, the collected prostates were fixed and embedded for light microscopy and transmission electron microscopy. Cytochemical tests were employed to evidence collagen fibers (Masson s Trichrome, Picrosirius Hematoxylin), reticular fibers (Gõmõri s Reticulin) and elastic system (Weigert s Resorcin Fuchsin); glycoprotein secretory products (periodic Acid &Schiff); prostatic nuclear and mitotic phenotypes (Feulgen s Reaction). It has also been done usual staining to general morphological analysis of the prostate. The morphometric stereological analysis of the normal and treated female prostate was realized to value statistica1ly the alteration suffered by the glands after hormonal administration. The results show that the normal female prostate of the gerbil is morphologica1ly similar to the male prostate, they have the same cell types and the same characteristics sttuctural pattem, what a1lows it is a good experimental model to studies of the prostate. In addition, the treated prostates with testosterone show a great development during the first phases of the hormonal administration, increasing foU! times the initial number of acini and ducts. The epithelial cells show themselves high and voluminous, becoming more actives in the secretion processes. The stroma has become thicker in spite of it has not been demonstrated significative modification in its relative frequency. Meanwhile, at the end of the treatment it has been observed a successive decrease in the prostatic deve1opment. The prostates treated with testosterone during 21 days have shown a similar number of acini and ducts to normal prostate and secretory epithelium less deve1oped. These results suggest that testosterone has produced a initial positive effect in the gerbil female prostate, becoming less efficient in the last phases of the treatment. By this way, it is supposed that the continued exposition to testosterone could have provoked the activation of endogens factors, that are able to inhibit part of androgenic stimuli upon the female prostates at the last phases of the hormonal administration

ASSUNTO(S)

testosterona prostata estereologia

ACESSO AO ARTIGO

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