AvaliaÃÃo da atividade antitumoral em extrato de Indigofera suffruticosa Mill

AUTOR(ES)

Cleideana Bezerra da Silva

DATA DE PUBLICAÇÃO

2008

RESUMO

Indigofera suffruticosa Mill is a shrub of the family Fabaceae popularly known as anil. Is a plant distributed worlwidely, and is utilized in the popular medicine against diverse problem of health. This study evaluated toxicological actions of the aqueous extract of leaves of I. suffruticosa the antitumor activity on carcinoma de Ehrlich (EC) cell and the influence of this extract on serum total cholesterol and triglycerides levels in mice. Were realized assays of acute toxicity by oral and intraperitoneal (i.p.) route in male mice, where was observed stimulant effects followed of depressors effects, after of the extract administration. The doses utilized were of 490 to 850 mg/kg by intraperitoneal route, where was esteemed the LD50 values in 750,6 mg/kg and 1000 to 5000 mg/kg by oral route, nevertheless, no death was notify by this administration route, only some sings toxic. The toxicity of the extract also was tested front the Artemia salina that showed a LC50 of 127 μg/mL. Treatment (i.p.) of normal Swiss white mice (n = 5) with extract of I. suffruticosa, with dose of 50 and 100 mg/kg, not presented significant differences in the serum of total cholesterol and triglycerides levels. After, the treatment (i.p.) with the extract, was observed a significant (p <0.001) reduction by 75.5% and 63.9%, on the size tumor of Ehrlich in mice, when was utilized doses of 50 e 100 mg/kg, respectively. The I. suffruticosa presented toxicity moderate and exhibited significant antitumor activity in EC â bearing mice, indicating that the same has medicinal propriety

ASSUNTO(S)

fabaceae indigofera suffruticosa anil fabaceae atividade antitumoral carcinoma de ehrlich indigofera suffruticose ehrlich carcinome bioquimica antitumor activity

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