Atividade antinociceptiva e antitumoral de compostos isolados da Pterodon pubescens Benth. (Leguminosae- papilionoidea) / Antinociceptive and antitumor activity of compounds isolated from Pterodon pubescens Benth. (Leguminosae- papilionoidea)

AUTOR(ES)
DATA DE PUBLICAÇÃO

2010

RESUMO

Pterodon pubescens Benth. species is widespread used in folk medicine. In this study, we demonstrated the antinociceptive (analgesic) and anti-tumor activity of compounds isolated from species. The most relevant results were: 1) bioactivityguided fractionation, isolation and identification of compounds using in vitro and in vivo assays; 2) identification of compounds 6α-acetoxy-7β-hydroxyvouacapan; 6α,7β-dihydroxyvouacapan-17β-oate methyl ester and 6α,7β-dihydroxyvouacapan-17β-metilenol with selectivity for prostate cell line (PC-3); 3) bioavailability of compounds geranylgeraniol and 6α,7β-dihydroxyvouacapan-17β-oate methyl ester with antitumor activity confirmed by in vivo assays; 4) analgesic modulation mechanisms of compounds geranylgeraniol and 6α,7β-dihydroxyvouacapan-17β-oate methyl ester related to inflammatory pain, neurogenic pain, glutamate receptors, vanilloid receptors, and possible exclusion of opioid receptors, 5) antiallodynic and anti-hyperalgesic activities of compounds geranylgeraniol and 6α,7β-dihydroxyvouacapan-17β-oate methyl ester demonstrating spinal and central activity; 6) the antinociceptive mechanisms related to the synthesis and / or release of serotonin (5-HT) for compound 6α,7β-dihydroxyvouacapan-17β-oate methyl ester, and specificity for serotonergic 5-HT3 and imidazoline I1 receptors for geranylgeraniol . The results presented in this study allowed us to determine the efficacy of compounds related to analgesic and anti-tumor activities, with potential for development as drugs.

ASSUNTO(S)

analgesia cancer produtos naturais analgesia cancer natural products

ACESSO AO ARTIGO

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