Arquitetura de computação em grade aplicada a saúde: um estudo de caso em bioinformática para oncologia. / Architecture of grid computing applied to health: a case study in bioinformatics for oncology.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2008

RESUMO

Cancer is currently the third cause of death in both sexes and among all age ranges. The Brazilian Ministry of Health reports that the high complexity of oncology care demands high financial costs and high technology. The activities of cancer research, prevention, diagnosis and treatment are increasingly becoming a multidisciplinary environment, including medicine, chemistry, genetic, bioinformatics and engineering. Those activities are responsible for the generation and management of huge quantities of data, which are geographically distributed among the treatment units on this country. This data needs to be integrated and processed, and its use is for the improvement of the cancer management and to enable research exchanges among institutions in the field. The processing of this information requires a large computational capacity. Particularly, we verify that bioinformatics handles a huge amount of data and has increasingly contributed for the research and diagnosis of several diseases, especially cancer. The proposal of this thesis is the research and development of a computational infrastructure based on grid computational technology to serve the requirements of high computational processing, related to the data from health care systems, in particular to bioinformatics in oncology. The use of grid computing technology in the Brazilian health scenario is challenging in terms of research and development, since this technology faces the complexity of data integration and processing using collaborative sharing of computational resources onto a multi-institutional geographically distributed environment. The validation of this work was in the application of some of the procedures that involve bioinformatics in oncology, especially the identification of genetic similarity, using an experimental implementation of the proposed architecture. The results obtained from the validation tests enabled us to evaluate the meeting of environment requirements, related with the needs of health sector in oncology, thus offering indications and technical directions to the use of grid computing technology in support of several activities related with the health sector.

ASSUNTO(S)

bioinformatics information technology tecnologia da informação oncology oncologia sistemas distribuídos health saúde bio-informática distributed systems

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