"Application of composite silicone rubber based graphite electrode in determination of pharmacological interest substances" / "Aplicação de eletrodos compósitos a base de grafite e borracha de silicone na determinação de substâncias de interesse farmacológico"

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

Studies regarding the applications of a graphite-silicone rubber composite as an electrode material have been performed and the results described in this work. The composite was used in the voltammetric determination of propranolol, an antihypertensive drug widely used in Brazil and rutin a flavonoid that presents both dilatation of blood vessels capabilities and antioxidative actions. The electrodes were prepared by using a suitable amount of graphite powder and silicone rubber in order to reach a 70% (graphite, w/w) composition. Cyclic voltammetric (CV) data were used in order to characterize the electrode material regarding useful potential window in different supporting electrolyte and pH. CV data were also used in order to evaluate the response of the composite electrode to the analytes. The quantitative measurements were performed with differential pulse voltammetry (DPV) with which analytical curves were obtained and used to estimate the detection limits and linear dynamic range. These data guided us towards the determination of the analytes in pharmaceutical formulations. The results were compared with those from standard methods with agreement in the 95% confidence level, according to the Student?s t-Test, in both cases. Lower limits of detection and larger linear dynamic ranges were observed for the composite when compared with those from the glassy carbon electrode under the same experimental conditions.

ASSUNTO(S)

formulações farmacêuticas voltametria pharmaceutical formulation voltammetry eletrodo compósito de grafite e borracha de silicone graphite silicone rubber composite

ACESSO AO ARTIGO

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