Pharmaceutical Formulation
Mostrando 1-12 de 106 artigos, teses e dissertações.
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1. Effect of two oral formulations of cannabidiol on responses to emotional stimuli in healthy human volunteers: pharmaceutical vehicle matters
Objective: To compare plasma concentrations of cannabidiol (CBD) following oral administration of two formulations of the drug (powder and dissolved in oil), and to evaluate the effects of these distinct formulations on responses to emotional stimuli in healthy human volunteers. Methods: In a randomized, double-blind, placebo-controlled, parallel-group desi
Brazilian Journal of Psychiatry. Publicado em: 2022
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2. Eco-friendly multivariant green analytical technique for the estimation of ketoconazole by UV spectroscopy in bulk and cream formulation
The pharmaceutical industries are focusing on Green Analytical Chemistry principles like miniaturization, eco-friendly solvent usage, waste recycling, and analyst safety for sustainable results. A simple, eco-friendly sensitive and effective extraction and multivariant green analytical method to estimate ketoconazole in bulk and cream formulation were develo
Química Nova. Publicado em: 2022
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3. EVOLUÇÃO DA LEGISLAÇÃO E DAS TÉCNICAS ANALÍTICAS APLICADAS A ESTUDOS DE ESTABILIDADE DE INSUMOS E PRODUTOS FARMACÊUTICOS
Stability is an important parameter to evaluate the quality, safety and efficacy of drug substances and pharmaceutical products. The stability studies aim to determine the ability of a formulation to maintain its specifications, in order to establish shelf life and recommended storage conditions. Despite the extensive relevance, until the 1980’s the stabil
Quím. Nova. Publicado em: 20/07/2020
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4. Novel PEG 4000 derivatives and its use in controlled release of drug indomethacin
The insertion of functional groups in polymer compounds may facilitate their interaction with different drugs. PEG polymers are widely used for their low melting point, low toxicity, drug compatibility, and hydrophilicity. They are used as pharmaceutical excipients for the formulation of conventional or modified released drugs and are designed to be upgraded
Quím. Nova. Publicado em: 2020-06
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5. Preformulation of a liquid dosage formulation of captopril for pediatric use: drug-excipient compatibility and stability studies
Currently, medications used in children are typically modified from pharmaceutical dosage forms designed for adults. Captopril is widely adapted to liquid formulations for use in hospitals. Its stability in the aqueous medium is reduced since it undergoes oxidation producing captopril disulfide (its main metabolite). The aim of this formulation study was to
Braz. J. Pharm. Sci.. Publicado em: 20/12/2019
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6. Application of quality by design approach in RP-HPLC method development for simultaneous estimation of saxagliptin and dapagliflozin in tablet dosage form
A simple, sensitive, precise, accurate and robust high performance liquid chromatographic method has been developed for simultaneous estimation of saxagliptin (SAXA) and dapagliflozin (DAPA) in pharmaceutical formulation. Design of experiments (DoE) was applied for multivariate optimization of the experimental conditions of RP-HPLC method. Risk assessment wa
Braz. J. Pharm. Sci.. Publicado em: 24/10/2019
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7. Development of a generic method for the determination of proton-pump inhibitors by capillary zoneelectrophoresis
A generic capillary zone electrophoresis method was developed for the analysis of four proton pump inhibitors: omeprazole, pantoprazole, lansoprazole and rabeprazole. During preliminary analysis screening of phosphate buffers at different pH levels was performed, in order to determine the optimum pH domain suitable for the simultaneous determination of all s
Braz. J. Pharm. Sci.. Publicado em: 30/09/2019
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8. Potency of nano-antibacterial formulation from Sargassum binderi against selected human pathogenic bacteria
Seaweeds constitutes an abundant marine reserve that can be harnessed as source of new pharmaceutical agents. Sargassum binderi Sonder ex J. Agardh is a brown seaweed that is predominantly available from December to March in the Red Sea, Jazan, Kingdom of Saudi Arabia (KSA). In this study, three extracts were isolated using three different techniques, and we
Braz. J. Pharm. Sci.. Publicado em: 08/04/2019
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9. Consumer perception of generic drug packages and its influence on product choice: a study in Minas Gerais, Brazil
Resumo A variedade de rótulos genéricos disponíveis tem sido marcante no setor farmacêutico nacional o que possibilita ao consumidor ampla liberdade de escolha dentre as várias apresentações existentes para um mesmo medicamento. Reconhecidas como equivalentes em qualidade e eficácia, essas apresentações diferem entre si apenas em pontos externos
Gest. Prod.. Publicado em: 28/03/2019
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10. Fatty acid composition of vegetable oil blend and in vitro effects of pharmacotherapeutical skin care applications
Vegetable oils have been used for a plethora of health benefits by their incorporation in foods, cosmetics, and pharmaceutical products, especially those intended for skin care. This study aimed to investigate the cutaneous benefits of a vegetable oil blend (VOB) formulation and its fatty acid composition. The anti-inflammatory activity was studied in macrop
Braz J Med Biol Res. Publicado em: 14/02/2019
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11. Stability indicating RP-HPLC method development and validation of cefepime and amikacin in pure and pharmaceutical dosage forms
A simple, accurate, isocratic stability indicating RP-HPLC method was developed for the determination of cefepime and amikacin in Pure and its pharmaceutical formulations. The method consists of methanol: acetonitrile:acetate buffer 75:20:05 (v/v) mobile phase at pH 5.1 with C18 column as stationary phase. The flow rate and detection wave length were 1.0 mL/
Braz. J. Pharm. Sci.. Publicado em: 29/11/2018
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12. Pharmaceutical development of tablets containing a spray-dried optimized extract from Lippia origanoides H. B. K.: influence of excipients and toxicological assessment
ABSTRACT Lippia origanoides is a honey shrub which has showed hypotensive potential assessed by in vivo studies. The aim of this work is the development of a pharmaceutical formulation composed by an optimized extract obtained from aerial parts of L. origanoides. The quantification of the naringenin marker in the dry extract and tablets developed was perform
Braz. J. Pharm. Sci.. Publicado em: 26/07/2018