Aplicação da ressonancia magnetica nuclear de carbono-13 na analise conformacional e determinação estrutural de alcaloides bisbenzilisoquinolinas

AUTOR(ES)

Luzia Koike

DATA DE PUBLICAÇÃO

1982

RESUMO

An analysis of C NMR of five series of bisbenzylisoquinoline alkaloids was carried out and the chemical shifts of more than forty compounds were assigned. The viability of the Birch reaction in the structure determination of Repanduline 3 and Dieline 4 was also undertaked. For this purpose three diphenyl-ethers models were synthesized and submitted to metal in liquid amonia condition. Although the optimum conditions of Birch reaction were not applied to the natural products the behaviour of the model compounds indicated that the methylenedioxy of Repanduline 3 should be transformed to methoxy groups prior to this reaction. The association.of H and C NMR data revealed some features of the preferred conformation of these very interesting macrocyclic compounds.

ASSUNTO(S)

alcaloides ressonancia magnetica nuclear carbono - compostos

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