AÃÃo dos Ãcidos graxos poliinsaturados essenciais na sÃndrome de tensÃo prÃ-menstual e as repercussÃes sobre a prolactina e o colesterol total

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

BACKGROUND: Essential fatty acids (EFA) deficiency has been implicated as a possible contributing factor to the premenstrual syndrome (PMS) when determining lower seric concentration of Prostaglandin E1 (PGE1). Several studies have reported a lower intracellular EFA and PGE1 concentration in women with PMS. Thus, it has been suggested that EFAâs supplementation may improve symptoms in women with PMS. OBJECTIVE: To compare the essential fatty acids effectiveness in the treatment of the premenstrual tension syndrome and to verify if It has difference in the symptoms when the double of the dose is used. It was observed if such medication determines alterations in the serics levels of prolactin and total cholesterol. METHOD: After a 2-month observational period, women with a regular menstrual cycle (from 25-35 days) who were affected by PMS (determined by the Prospective Record of the Impact and Severity of Menstrual Symptoms âPRISM- calendar) [n = 45] were randomly assigned to six cycles of double-blind, placebo-controlled treatment with 01 gram or 02 grams of essential fatty acids. Sanguineous samples had been harvested before and after 3 and 6 months of treatment. RESULTS: Both essential fatty acids groups significantly improved when compared with placebo group as assessed by total premenstrual PRISM scores after 06 months of treatment. After 3 months, the mean total PMS score (primary endpoint), as assessed by the investigator using PRISM calendar, It was significantly lower than before the therapy and significantly lower than the placebo group. After six months, these data was still more significant. The two grams EFAâs group had gotten clinical reply faster than one gramâs group; however it did not have difference when the data with six months of the administration were compared. Gradual and significant placebo group improvement was observed, however this was well less significant of what the observed ones in the two other groups. Didnât have significant difference in the prolactin and total cholesterol serics levels` in elapsing of the study. The Essential fatty acids was well tolerated, without important treatment-related adverse event reported. CONCLUSIONS: We concluded that essential fatty acids treatment was effective in reducing premenstrual symptoms in women with PMS and, in the used doses, they had not determined alterations in the prolactin and total cholesterol serics levels

ASSUNTO(S)

colesterol total neurologia prolactin sÃndrome prÃ-menstrual prolactin premenstrual syndrome total cholesterol essential fatty acids Ãcidos graxos essenciais

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