Tratamento da sÃndrome da TensÃo PrÃ-Menstrual com vitamina B6: resposta terapÃutica e avaliaÃÃo de risco da neurotoxicidade perifÃrica

AUTOR(ES)
DATA DE PUBLICAÇÃO

2003

RESUMO

Premenstrual syndrome is a situation that reaches a great part of feminine population. According with ICD-10, history of few physical or behaviors symptoms that occur on cyclic form during luteal phase of menstrual cycle is requested and disappears within a few days since the beginning of menstruation. Despite many drugs to premenstrual tension treatment, a challenge for medical specialist continues to exist and what medication is appropriated to abolish the disagreeable symptoms stay in doubt. Vitamin B6 has been used like one of the therapeutic options; but the ideal dose was not still established. In this study, the objective was to evaluate the clinical and electromyography responses in the premenstrual syndrome after using of vitamin B6 as monotherapy. This study was descriptive and serial cases, with pattern of thirty five women attended in headache clinic of the Hospital das ClÃnicas - Universidade Federal de Pernambuco, from november 2002 to may 2003. The response to vitamin B6 was evaluated through the observation of symptoms like discouragement, inability to concentration, depression, anxiety, irritability, insomnia, somnolence, discomfort and distension abdominal, lumbar pain, oliguria, breast edema and breast tenderness, pain and edema in the legs, all these were monthly compared with the values before treatment, by McNemar test, for four consecutive menstrual cycles. The patientâs satisfaction about the utilization of vitamin B6 was related like improvement of symptoms since second menstrual cycle, proved by significant statistical analysis (p ≤ 0,05) in third and fourth menstrual cycles of treatment. The association between the age of beginning of menstrual symptoms and the age of menarche presented statistical differences with p <0,001 and by the Pearsonâs correlation any association was not verified. The patients with headache related to premenstrual syndrome obtained significant improvement after use of vitamin B6. The amplitude of the sensitive potential and sensitive conduction velocity of right and left sural nerves, before and after using vitamin B6, were evaluated to peripheral neurotoxicity. We do not observe significant differences in the parameters measured and anyone of the patients presented electromyography alteration. We concluded that vitamin B6 in dose of 600mg/day from fourteen day until the first day of next cycle, for four consecutive menstrual cycles is efficient and security in treatment of premenstrual syndromeâs symptoms and do not induce peripheral neuropathy, and so, we suggest like an important therapeutic alternative for these syndrome

ASSUNTO(S)

premenstrual tension tensÃo prÃ-menstrual vitamin b6 neurotoxicidade perifÃrica vitamina b6 peripheral neurotoxicity ciÃncias da saÃde

ACESSO AO ARTIGO

Documentos Relacionados