Apolipoprotein E
Mostrando 13-24 de 458 artigos, teses e dissertações.
-
13. A esplenectomia aumenta as lesões ateroscleróticas em camundongos deficientes em apoproteína E submetidos a uma dieta aterogênica
Atherosclerosis is an inflammatory immune disease associated with lipid accumulation in the intima layer of arteries. The spleen plays an important immune function, but its influence in development of atherosclerosis remains unclear. Evaluation of the role of the spleen in atherosclerosis is justified due to the high frequency of total splenectomies and the
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/08/2011
-
14. Neuropsychological and neurobiological markers of the preclinical stage of Alzheimer's disease
Dementia, especially Alzheimer's disease, has a high prevalence in the elderly population. Therefore, identifying individuals who are at a high risk for early diagnosis is crucial to allow both pharmacological and behavioral therapeutic interventions, which in some cases can delay the progression of dementia. This paper describes neuropsychological and neuro
Psychology & Neuroscience. Publicado em: 2011
-
15. Mecanismo antiinflamatÃrio do peptÃdeo mimÃtico da ApolipoproteÃna E (COG 133) na recuperaÃÃo da mucosite intestinal induzida por 5-Fluoruracil em camundongos Swiss. / echanism of anti-inflammatory peptide mimetic of Apolipoprotein E (COG 133) in the recovery of intestinal mucositis induced by 5-fluorouracil in mice.
O cÃncer à uma doenÃa grave que atinge milhares de pessoas no mundo, possuindo altos Ãndices de morbidade e mortalidade. Atualmente existem diversos alvos terapÃuticos no tratamento do cÃncer, um deles reside no fato de inibir a replicaÃÃo do DNA impossibilitando a cÃlula tumoral de se duplicar como à o caso do 5-fluoruracil (5-FU).O objetivo do tr
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/09/2010
-
16. Interleukin-8-251T > a, interleukin-1α-889C > t and apolipoprotein e polymorphisms in Alzheimer's disease
An inflammatory process has been involved in numerous neurodegenerative disorders such as Parkinson's disease, stroke and Alzheimer's disease (AD). In AD, the inflammatory response is mainly located in the vicinity of amyloid plaques. Cytokines, such as interleukin-8 (IL-8) and interleukin-1α (IL-1α), have been clearly involved in this inflammatory process
Genetics and Molecular Biology. Publicado em: 19/11/2010
-
17. Association of apolipopetein E polymorphism with plasma lipids and Alzheimer's disease in a southern brazilian population
Apolipoprotein E (protein: apo E; gene: APOE) plays an important role in the multifactorial etiology of both Alzheimers disease (AD) and lipid level concentrations. The polymerase chain reaction (PCR) was used to investigate the APOE gene polymorphism in 446 unrelated Caucasians, among them 23 AD patients, and 100 Afro-Brazilians living in Porto Alegre, Br
Publicado em: 2010
-
18. Associação do Genótipo da apolipoproteína E e diferentes intensidade de exercício na lipemia pós-prandial de homens jovens
Introduction: Postprandial lipemia (PPL) refers to a series of metabolic events related to the increased concentration of circulating lipids, which occurs after the consumption of fats intake. It is an indirect stimulation of atherosclerosis, since it promotes the formation of atherosclerotic plaques through the wall of the arteries. It is associated with in
Publicado em: 2010
-
19. Oral rapamycin attenuates atherosclerosis without affecting the arterial responsiveness of resistance vessels in apolipoprotein E-deficient mice
The objective of the present study was to assess the effects of the immunosuppressant rapamycin (Rapamune®, Sirolimus) on both resistance vessel responsiveness and atherosclerosis in apolipoprotein E-deficient 8-week-old male mice fed a normal rodent diet. Norepinephrine (NE)-induced vasoconstriction, acetylcholine (ACh)- and sodium nitroprusside (SNP)-indu
Brazilian Journal of Medical and Biological Research. Publicado em: 06/11/2009
-
20. Association between apolipoprotein E genotype, serum lipids, and colorectal cancer in Brazilian individuals
We evaluated genetic variants of apolipoprotein E (APOE HhaI) and their association with serum lipids in colorectal cancer (CRC), together with eating habits and personal history. Eight-seven adults with CRC and 73 controls were studied. APOE*2 (rs7412) and APOE*4 (rs429358) were identified by polymerase chain reaction-restriction fragment length polymorphis
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-05
-
21. Effects of APOE, APOB and LDLR variants on serum lipids and lack of association with xanthelasma in individuals from Southeastern Brazil
Xanthelasma might be a clinical manifestation of dyslipidemia, a recognized risk factor for coronary artery disease. We investigated the association of apolipoprotein E (APOE HhaI), apolipoprotein B (APOB XbaI and Ins/Del) and LDL receptor (LDLR AvaII and HincII) gene polymorphisms with lipid profiles in 100 Brazilians with xanthelasma and 100 controls. Alle
Genetics and Molecular Biology. Publicado em: 06/03/2009
-
22. Impacto da esquistossomose mansÃnica no perfil lipÃdico e nas concentraÃÃes plasmÃticas das apolipoproteÃnas A-I e B
A esquistossomose à uma doenÃa parasitÃria intravascular presente em regiÃes de climas tropical e subtropical que acomete, aproximadamente, 200 milhÃes de pessoas no mundo. Estudos utilizando animais infectados tÃm demonstrado alteraÃÃes no metabolismo de lipÃdios. Entretanto, estudos tÃm reportado diferenÃas entre as alteraÃÃes observadas nos a
Publicado em: 2009
-
23. Fatores prÃ-aterotrombÃticos associados à SÃndrome MetabÃlica X na populaÃÃo de Pernambuco â Nordeste â Brasil
Metabolic Syndrome X (MSX) is a cluster of at least three metabolic disorders, among which insulin resistance/compensatory hyperinsulinemia, hyperglycemia, obesity and/or abdominal obesity, hypertension, characteristic dyslipidemia with hypertriglyceridemia and/or reduction of levels of cholesterol in high-density lipoprotein (HDL-c), and other pro-atherothr
Publicado em: 2009
-
24. Sinalização intracelular e expressão de receptores mediados por LDL modificada e peptídeos da apolipoproteínaB-100 em monócitos/macrófagos humanos. / Intracellular signaling and receptor expression mediated by modified LDL and apolipoproteinB-100 peptides in human monocytes/macrophages.
The Low Density Lipoprotein (LDL) may undergo oxidative or enzymatic modifications, producing lipid or proteic compounds that interact with macrophages, contributing to inflammatory response in the atherosclerosis. Into the arterial intima, the macrophages interact with minimally modified LDL (LoxLDL) and with highly oxidized LDL (HoxLDL). Moreover, in the a
Publicado em: 2009