Associação do Genótipo da apolipoproteína E e diferentes intensidade de exercício na lipemia pós-prandial de homens jovens

AUTOR(ES)
DATA DE PUBLICAÇÃO

2010

RESUMO

Introduction: Postprandial lipemia (PPL) refers to a series of metabolic events related to the increased concentration of circulating lipids, which occurs after the consumption of fats intake. It is an indirect stimulation of atherosclerosis, since it promotes the formation of atherosclerotic plaques through the wall of the arteries. It is associated with increased blood clotting, endothelial dysfunction and increased systemic inflammation. Exercise appears to be an effective tool in the attenuation or reduction of PPL. However, some genetic polymorphisms may modulate the response of the PPL through the exercise, for example, apolipoprotein E (apoE) genotype. Objectives: To investigate the effect of aerobic exercise intensity on the PPL according to apoE genotype. Materials and Methods: The sample consisted of 30 subjects with a mean age of 22 2.1 years in 3 groups: e2 (1 subject e2/2 and 9 subjects e2/3), group e3 (10 subjects e3/3) and group e4 (10 subjects e3/4). After participating in a maximal test, the subjects appeared on three different days with a 48h interval between experiments in randomized order to perform continuous exercise at a speed corresponding to 85% of anaerobic threshold (AT) - EX-CON, intermittent exercise at 115% of AT - EX-INT, or a control day. After the EX-CON and EX-INT to an energy expenditure of 500 calories, or control day, subjects consumed a drink fatty (DF) - 1g fat / kg, totaling 9.4% protein, 19.6% carbohydrate and 71% fat. Blood samples were taken before exercise and every hour after the DF. Was measured Triglyceride (TG), total cholesterol (TC), HDL, LDL, VLDL and insulin levels were measured. The PPL was analyzed by the kinetics of the variables measured, and the analysis of the area under the curve (AUC). Observing a significant difference in some variable, LSD and Games-Howell multiple comparison test were conducted to identify relevant contrasts between means with and without normal distribution respectively. Statistical analysis was performed with SPSS for Windows, version 11.5. Results: Both CON-EX and EX-INT, were effective in reducing the levels of TG in the second, third and fourth hours, and the ASC. The VLDL differed from the control in the second hour (EX-CON) and fourth hours (EX-CON and EX-INT) after DF. Among the polymorphisms of apoE, the variables of TG, HDL and VLDL did not differ between groups e2 / e3 / e4. However, the TC one to three hours, and LDL in the first two hours, and AUC of both were significantly higher in the e4, when compared with the e2. In the interaction of apoE with exercise, it was found that the EX-CON, additionally, the AUC of total cholesterol levels of subjects e4 was higher than e2, and EX-INT, the ASC of TC and LDL were higher in the e4 than both (e2 / e3). Conclusion: The EX-CON and EX-INT were effective in reducing the PPL compared with the control day in total group. There was no difference between CON-EX and EX-INT. People belonging to the e4 allele had greater lipid responses that e2. The EX-CON and EX-INT were effective in reducing the PPL for both groups e2 / e3, and e2 was more responsive to the moderate continuous exercise, and e3 by intense intermittent exercise. When comparing groups, the AUC of CT of the subjects e4 was higher than e2 in EX-CON, and, the ASC of TC and LDL were higher in the e4 for both e2 / e 3 in EX-INT.

ASSUNTO(S)

apolipoprotein e genótipo postprandial lipemia continuum exercise exercício intermitente genotype exercício contínuo lipemia pós-prandial apolipoproteína e intermittent exercise educacao fisica

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