Antiviral Drugs
Mostrando 1-12 de 298 artigos, teses e dissertações.
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1. Quando está indicado realizar quimioprofilaxia com Oseltamivir?
Após exposição a caso suspeito ou confirmado de influenza, recomenda-se a realização de quimioprofilaxia com oseltamivir para os seguintes casos:
– pessoas com risco elevado de complicações, não vacinadas ou vacinadas há menos de duas semanas;
– crianças com menos de 9 anos de idade, com condições ou fatores de risco, primovaci
Núcleo de Telessaúde Rio Grande do Sul. Publicado em: 12/06/2023
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2. Qual a diferença do Oseltamivir em relação aos antivirais usados para tratamento de Herpes e HIV? Qual o mecanismo de ação de cada um deles?
O Oseltamivir, classificado como inibidor da liberação da desmontagem viral, é um antiviral que inibe de forma seletiva a enzima neuroaminidase específica do vírus influenza, que é essencial para a entrada e liberação desse vírus nas células humanas. Desta forma, o oseltamivir, administrado por via oral, inibe a replicação dos vírus influenza
Núcleo de Telessaúde Rio Grande do Sul. Publicado em: 12/06/2023
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3. Synthesis and Anti-Chikungunya Virus (CHIKV) Activity of Novel 1,4-Naphthoquinone Sulfonamide and Sulfonate Ester Derivatives
Chikungunya virus (CHIKV) is a re-emerging disease caused by an alphavirus of the Togaviridae family. Since its first description in 1952, the disease has spread worldwide, affecting populations in both tropical and temperate countries. To date, there is no licensed vaccine or specific pharmacological treatment. Therefore, there is an increasing urgency in d
Journal of the Brazilian Chemical Society. Publicado em: 2022
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4. DFT, Molecular Docking, and ADME/Tox Screening Investigations of Market-Available Drugs against SARS-CoV-2
A series of drugs was investigated to determine structural, electronic and pharmacological properties, as well as the molecular affinity for the main protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The drugs were submitted to density functional theory calculations to optimize structures and predict binding preferences. The optimized
J. Braz. Chem. Soc.. Publicado em: 2021-08
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5. Focusing on thyroid nodules in suspense: 10-15 mm with repeat cytology, Category III, the Bethesda System for Reporting Thyroid Cytopathology, TBSRTC
SUMMARY OBJECTIVES: Although research in relation to new vaccines for the coronavirus, SARS-CoV-2 (COVID-19), is ongoing, it has been reported that medical teams are also considering the use of antiviral drugs in patients in order to verify their effectiveness when infection signs and symptoms present, mainly in stages one and two of the disease. METHODS:
Rev. Assoc. Med. Bras.. Publicado em: 2021-02
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6. Effectiveness of early therapeutic intervention in phases one and two after COVID-19 infection: systematic review
SUMMARY OBJECTIVES: Although research in relation to new vaccines for the coronavirus, SARS-CoV-2 (COVID-19), is ongoing, it has been reported that medical teams are also considering the use of antiviral drugs in patients in order to verify their effectiveness when infection signs and symptoms present, mainly in stages one and two of the disease. METHODS:
Rev. Assoc. Med. Bras.. Publicado em: 2021-02
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7. Identification of Potential Inhibitors of Severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Main Protease from Non-Natural and Natural Sources: A Molecular Docking Study
So far, there is neither a vaccine nor a specific antiviral drug to prevent or treat COVID-19 (coronavirus disease) infection. Recent studies have been done to investigate the capacity of human immunodeficiency virus type 1 (HIV-1) protease inhibitors be used in the treatment of COVID-19 patients. Some of those drugs have shown to be promising. Natural chemi
J. Braz. Chem. Soc.. Publicado em: 2020-12
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8. Crystal Structure and 1H NMR Experimental and Theoretical Study of Conformers of 5-Methyl-1-(4’-methylphenylsulfonylamino)-1H-[1,2,3]-triazole-4-carboxylic Acid Ethyl Ester and 5-Methyl-1-(phenylsulfonylamino)-1H-[1,2,3]-triazole-4-carboxylic Acid Ethyl Ester
We reported experimental and theoretical investigation of conformers of 1,2,3-triazole derivatives, substances of exclusively synthetic origin, subject of extensive studies, because of several biological properties, such as antiviral, antimicrobial and antileishmaniasis. We reported molecular/supramolecular X-ray structures of antiophidian compounds I and II
J. Braz. Chem. Soc.. Publicado em: 2020-05
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9. Influence of antiretroviral therapy on bone metabolism of patients with chronic hepatitis B: a review
Abstract Hepatitis B is a major public health problem worldwide and associated with significant mortality. To prevent or delay the deleterious effects of chronic infection by the hepatitis B virus, patients should be carefully followed, and antiviral therapy indicated according to specific recommendations. Currently, available drugs inhibit viral replication
Rev. Soc. Bras. Med. Trop.. Publicado em: 03/10/2019
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10. Vegetative chronic genital herpes with satisfactory response to imiquimod
Abstract Vegetative chronic genital herpes is an atypical presentation of herpes simplex 2 that it is usually seen in patients coinfected with human immunodeficiency virus. Clinically, it is characterized by extensive ulcers that evolve to chronification and hypertrophic pseudotumor forms. Antiviral drugs are recommended for the treatment, and acyclovir is t
An. Bras. Dermatol.. Publicado em: 09/05/2019
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11. Hepatitis C in Hemodialysis Units: diagnosis and therapeutic approach
Resumo De acordo com os dados do último censo da Sociedade Brasileira de Nefrologia (SBN), a prevalência de portadores do vírus da hepatite C (HCV) nas unidades de hemodiálise (UH) no Brasil é de 3,3%, cerca de três vezes maior do que é observado na população geral brasileira. Muitas vezes, os profissionais que trabalham nas UH deparam-se com situa�
J. Bras. Nefrol.. Publicado em: 18/02/2019
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12. An eye on hepatitis C: a review
RESUMO Esta revisão objetiva alertar os oftalmologistas sobre as consequências oculares que levam ao diagnóstico da infecção pelo vírus da Hepatite C. Além disso, neste contexto, os efeitos de drogas antigas e novas são discutidos no cenário oftalmológico. A importância do diagnóstico precoce e do tratamento curativo da doença tem sido relatada
Arq. Bras. Oftalmol.. Publicado em: 24/01/2019